Improved pharmacokinetic and pharmacodynamic profiles of insulin analogues using InsuPatch, a local heating device

Zohar Landau, David Klonoff, Irina Nayberg, Dmitry Feldman, Shmuel Boris Levit, Dan Lender, Ofri Mosenzon, Itamar Raz, Julio Wainstein

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: Previous studies have shown that heating the insulin injection site may accelerate insulin absorption. We investigated the pharmacological profile of insulin administered with InsuPatch, a local skin-heating device. Methods: In this randomized, crossover study carried out in 56 subjects with type 1 diabetes treated with insulin pump [mean age 32±13.5 years; 23 women; HbA1c:7.8±0.9% (62±10 mmol/mol) (mean+/-standard deviation)]. Euglycemic glucose clamps were performed after administration of 0.15 units/kg of short-acting insulin analogues. Each subject underwent three clamp procedures: two with the InsuPatch device (day 1 and day 3) and one without the device (day 1 control). The primary endpoints were the following: (1) the change in the area under the curve (AUC) of insulin during the first 60 min post-insulin bolus on day 1 with the InsuPatch device versus day 1 control and (2) parameters to assess the safety of using the device. Results: The area under the curve of insulin during the initial 60 min (insulin AUC0-60) after insulin bolus was increased by 29.7±7% on day 1 InsuPatch versus day 1 control (p<0.01). Maximal post-insulin bolus concentration was 57 mU/L on day 1 InsuPatch versus 47.6 mU/L on day 1 control (p<0.01). On day 3 InsuPatch, insulin AUC0-60 was increased by 27.9±72% versus day 1 InsuPatch (p<0.01). Maximal insulin concentration was 70.4 mU/L versus 57 mU/L, respectively (p=0.05). Conclusions: The use of the heating device upon administration of short-acting insulin analogues in pump-treated type 1 diabetic patients was found to enhance insulin absorption. This heating device may therefore serve to achieve better meal insulin coverage.

Original languageEnglish
Pages (from-to)686-692
Number of pages7
JournalDiabetes/Metabolism Research and Reviews
Volume30
Issue number8
DOIs
StatePublished - 1 Nov 2014
Externally publishedYes

Keywords

  • Insulin
  • Pharmacodynamic
  • Pharmacokinetic

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