Improved survival of island flaps after prolonged ischemia by perfusion with superoxide dismutase

Amiram Sagi, Michael Ferder, David Levens, Berish Strauch

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Perfusion of rat groin flaps after 10 and 11 hours of complete ischemia with superoxide dismutase, an oxygen free-radical scavenger, significantly improved the survival of these flaps. This finding provides further evidence for the important role that oxygen-derived free radicals play in ischemic injury. The study also demonstrates that while restoration of blood supply alone is not enough to ensure tissue survival after prolonged ischemia, chemical agents can be utilized to achieve viable flaps beyond what was believed to be “a point of no return.

Original languageEnglish
Pages (from-to)638-642
Number of pages5
JournalPlastic and Reconstructive Surgery
Volume77
Issue number4
DOIs
StatePublished - 1 Jan 1986
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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