Improvement of extrapyramidal symptoms following dehydroepiandrosterone (DHEA) administration in antipsychotic treated schizophrenia patients: A randomized, double-blind placebo controlled trial

Tali Nachshoni; Tanya Ebert; Yehuda Abramovitch; Miriam Assael-Amir; Moshe Kotler; Rachel Maayan; Abraham Weizman; Rael D. Strous

doi:10.1016/j.schres.2005.07.029

Improvement of extrapyramidal symptoms following dehydroepiandrosterone (DHEA) administration in antipsychotic treated schizophrenia patients: A randomized, double-blind placebo controlled trial

Tali Nachshoni, Tanya Ebert, Yehuda Abramovitch, Miriam Assael-Amir, Moshe Kotler, Rachel Maayan, Abraham Weizman, Rael D. Strous

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Recent investigation in schizophrenia indicated dehydroepiandrosterone (DHEA) levels to be inversely correlated with extrapyramidal symptomatology (EPS). This study thus investigates the effect of DHEA administration on medication-induced EPS. Inpatients with schizophrenia or schizoaffective disorder were randomized in double-blind fashion to receive either 100 mg DHEA or placebo in addition to a constant dosage of antipsychotic medication. Parkinsonism showed a favorable effect of DHEA with a significant time effect (p < 0.0001), as well as a significant group by time interaction (p < 0.05) and with no change noted on akathisia. Change of DHEA blood levels was negatively associated with change of Parkinsonism (p < 0.05) as well as with change of total EPS ratings (p < 0.05). DHEA appears to demonstrate a significant effect on EPS, with improvement observed particularly in Parkinsonian symptoms.

Original language	English
Pages (from-to)	251-256
Number of pages	6
Journal	Schizophrenia Research
Volume	79
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2005.07.029
State	Published - 15 Nov 2005
Externally published	Yes

Keywords

Dehydroepiandrosterone
DHEA
EPS
Extrapyramidal signs
Parkinsonism
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2005.07.029

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Nachshoni, T., Ebert, T., Abramovitch, Y., Assael-Amir, M., Kotler, M., Maayan, R., Weizman, A., & Strous, R. D. (2005). Improvement of extrapyramidal symptoms following dehydroepiandrosterone (DHEA) administration in antipsychotic treated schizophrenia patients: A randomized, double-blind placebo controlled trial. Schizophrenia Research, 79(2-3), 251-256. https://doi.org/10.1016/j.schres.2005.07.029

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title = "Improvement of extrapyramidal symptoms following dehydroepiandrosterone (DHEA) administration in antipsychotic treated schizophrenia patients: A randomized, double-blind placebo controlled trial",

abstract = "Recent investigation in schizophrenia indicated dehydroepiandrosterone (DHEA) levels to be inversely correlated with extrapyramidal symptomatology (EPS). This study thus investigates the effect of DHEA administration on medication-induced EPS. Inpatients with schizophrenia or schizoaffective disorder were randomized in double-blind fashion to receive either 100 mg DHEA or placebo in addition to a constant dosage of antipsychotic medication. Parkinsonism showed a favorable effect of DHEA with a significant time effect (p < 0.0001), as well as a significant group by time interaction (p < 0.05) and with no change noted on akathisia. Change of DHEA blood levels was negatively associated with change of Parkinsonism (p < 0.05) as well as with change of total EPS ratings (p < 0.05). DHEA appears to demonstrate a significant effect on EPS, with improvement observed particularly in Parkinsonian symptoms.",

keywords = "Dehydroepiandrosterone, DHEA, EPS, Extrapyramidal signs, Parkinsonism, Schizophrenia",

author = "Tali Nachshoni and Tanya Ebert and Yehuda Abramovitch and Miriam Assael-Amir and Moshe Kotler and Rachel Maayan and Abraham Weizman and Strous, {Rael D.}",

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Nachshoni, T, Ebert, T, Abramovitch, Y, Assael-Amir, M, Kotler, M, Maayan, R, Weizman, A & Strous, RD 2005, 'Improvement of extrapyramidal symptoms following dehydroepiandrosterone (DHEA) administration in antipsychotic treated schizophrenia patients: A randomized, double-blind placebo controlled trial', Schizophrenia Research, vol. 79, no. 2-3, pp. 251-256. https://doi.org/10.1016/j.schres.2005.07.029

Improvement of extrapyramidal symptoms following dehydroepiandrosterone (DHEA) administration in antipsychotic treated schizophrenia patients: A randomized, double-blind placebo controlled trial. / Nachshoni, Tali; Ebert, Tanya; Abramovitch, Yehuda et al.
In: Schizophrenia Research, Vol. 79, No. 2-3, 15.11.2005, p. 251-256.

Research output: Contribution to journal › Article › peer-review

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Improvement of extrapyramidal symptoms following dehydroepiandrosterone (DHEA) administration in antipsychotic treated schizophrenia patients: A randomized, double-blind placebo controlled trial

Abstract

Keywords

ASJC Scopus subject areas

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