In vitro activity and potency of an intravenously injected antimicrobial peptide and its DL amino acid analog in mice infected with bacteria

Amir Braunstein; Niv Papo; Yechiel Shai

doi:10.1128/AAC.48.8.3127-3129.2004

In vitro activity and potency of an intravenously injected antimicrobial peptide and its DL amino acid analog in mice infected with bacteria

Amir Braunstein, Niv Papo, Yechiel Shai

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

We report that intravenous injection (3 mg/kg of body weight twice daily) of a diastereomer (containing 33% D amino acids) of an antimicrobial peptide, K₆L₆, (LKLLKKLLKKLLKLL-NH₂), but not the all-L-amino-acid parental peptide, cures neutropenic mice infected with gentamicin-sensitive Pseudomonas aeruginosa and gentamicin-resistant Acinetobacter baumannii bacteria. Various biophysical experiments suggest a membranolytic-like effect.

Original language	English
Pages (from-to)	3127-3129
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	48
Issue number	8
DOIs	https://doi.org/10.1128/AAC.48.8.3127-3129.2004
State	Published - 1 Aug 2004
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.48.8.3127-3129.2004

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abstract = "We report that intravenous injection (3 mg/kg of body weight twice daily) of a diastereomer (containing 33% D amino acids) of an antimicrobial peptide, K6L6, (LKLLKKLLKKLLKLL-NH2), but not the all-L-amino-acid parental peptide, cures neutropenic mice infected with gentamicin-sensitive Pseudomonas aeruginosa and gentamicin-resistant Acinetobacter baumannii bacteria. Various biophysical experiments suggest a membranolytic-like effect.",

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AU - Papo, Niv

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AB - We report that intravenous injection (3 mg/kg of body weight twice daily) of a diastereomer (containing 33% D amino acids) of an antimicrobial peptide, K6L6, (LKLLKKLLKKLLKLL-NH2), but not the all-L-amino-acid parental peptide, cures neutropenic mice infected with gentamicin-sensitive Pseudomonas aeruginosa and gentamicin-resistant Acinetobacter baumannii bacteria. Various biophysical experiments suggest a membranolytic-like effect.

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In vitro activity and potency of an intravenously injected antimicrobial peptide and its DL amino acid analog in mice infected with bacteria

Abstract

ASJC Scopus subject areas

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