In vitro activity of eravacycline and comparator agents against bacterial pathogens isolated from patients with cancer

Kenneth Rolston, Bahgat Gerges, Lior Nesher, Samuel A. Shelburne, Randall Prince, Issam Raad

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    Background: Bacterial infections are common in patients with cancer, and many bacteria have developed resistance to currently used antibiotics. Objectives: We evaluated the in vitro activity of eravacycline (a recently developed fluorocycline) and comparators against bacterial pathogens isolated from patients with cancer. Methods: Antimicrobial susceptibility testing was performed using CLSI-approved methodology and interpretive criteria for 255 Gram-positive and 310 Gram-negative bacteria. MIC and susceptibility percentage were calculated according to CLSI and FDA breakpoints when available. Results: Eravacycline had potent activity against most Gram-positive bacteria, including MRSA. Of 80 Gram-positive isolates with available breakpoints, 74 (92.5%) were susceptible to eravacycline. Eravacycline had potent activity against most Enterobacterales, including ESBL-producing organisms. Of 230 Gram-negative isolates with available breakpoints, 201 (87.4%) were susceptible to eravacycline. Eravacycline had the best activity among comparators against carbapenem-resistant Enterobacterales, with 83% susceptibility. Eravacycline was also active against many non-fermenting Gram-negative bacteria, with the lowest MIC90 value among comparators. Conclusions: Eravacycline was active against many clinically significant bacteria isolated from patients with cancer, including MRSA, carbapenem-resistant Enterobacterales, and non-fermenting Gram-negative bacilli. Eravacycline might play an important role in the treatment of bacterial infections in patients with cancer, and additional clinical evaluation is warranted.

    Original languageEnglish
    Article numberdlad020
    JournalJAC-Antimicrobial Resistance
    Volume5
    Issue number2
    DOIs
    StatePublished - 1 Apr 2023

    ASJC Scopus subject areas

    • Microbiology (medical)
    • Infectious Diseases
    • Immunology and Allergy
    • Microbiology
    • Immunology

    Fingerprint

    Dive into the research topics of 'In vitro activity of eravacycline and comparator agents against bacterial pathogens isolated from patients with cancer'. Together they form a unique fingerprint.

    Cite this