TY - JOUR
T1 - In vitro antiparasitic activity of microbial pigments and their combination with phytosynthesized metal nanoparticles
AU - Rahul, Suryawanshi
AU - Chandrashekhar, Patil
AU - Hemant, Borase
AU - Bipinchandra, Salunke
AU - Mouray, Elisabeth
AU - Grellier, Philippe
AU - Satish, Patil
N1 - Publisher Copyright:
© 2015 Elsevier Ireland Ltd.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Bioactive pigments were extracted and purified from cultures of Serratia marcescens and Chromobacterium violaceum. Spectroscopic, FTIR, and HPLC analyses showed prodigiosin and violacein as the principle molecules in the extract. Bioactive microbial pigments prodigiosin, violacein and their combinations with phytosynthesized silver and gold nanoparticles were studied for in vitro growth inhibition of Plasmodium falciparum and Trypanosoma brucei gambiense. Prodigiosin was found to be more effective than violacein for inhibition of both parasites in vitro. Specifically, combinations of the microbial pigment prodigiosin with metal nanoparticles showed a significant decrease in the IC50 values on both parasites (2.7 to 3.6 fold) without increase of cytotoxicity upon mammalian cells. The data may be useful for the microbial pigment based drug designing.
AB - Bioactive pigments were extracted and purified from cultures of Serratia marcescens and Chromobacterium violaceum. Spectroscopic, FTIR, and HPLC analyses showed prodigiosin and violacein as the principle molecules in the extract. Bioactive microbial pigments prodigiosin, violacein and their combinations with phytosynthesized silver and gold nanoparticles were studied for in vitro growth inhibition of Plasmodium falciparum and Trypanosoma brucei gambiense. Prodigiosin was found to be more effective than violacein for inhibition of both parasites in vitro. Specifically, combinations of the microbial pigment prodigiosin with metal nanoparticles showed a significant decrease in the IC50 values on both parasites (2.7 to 3.6 fold) without increase of cytotoxicity upon mammalian cells. The data may be useful for the microbial pigment based drug designing.
KW - Antimalarial
KW - Plasmodium falciparum
KW - Prodigiosin
KW - Trypanosoma brucei gambiense
KW - Violacein
UR - http://www.scopus.com/inward/record.url?scp=84930617979&partnerID=8YFLogxK
U2 - 10.1016/j.parint.2015.05.004
DO - 10.1016/j.parint.2015.05.004
M3 - Article
C2 - 25986963
AN - SCOPUS:84930617979
SN - 1383-5769
VL - 64
SP - 353
EP - 356
JO - Parasitology International
JF - Parasitology International
IS - 5
ER -
