In vitro antiparasitic activity of microbial pigments and their combination with phytosynthesized metal nanoparticles

Suryawanshi Rahul, Patil Chandrashekhar, Borase Hemant, Salunke Bipinchandra, Elisabeth Mouray, Philippe Grellier, Patil Satish

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Bioactive pigments were extracted and purified from cultures of Serratia marcescens and Chromobacterium violaceum. Spectroscopic, FTIR, and HPLC analyses showed prodigiosin and violacein as the principle molecules in the extract. Bioactive microbial pigments prodigiosin, violacein and their combinations with phytosynthesized silver and gold nanoparticles were studied for in vitro growth inhibition of Plasmodium falciparum and Trypanosoma brucei gambiense. Prodigiosin was found to be more effective than violacein for inhibition of both parasites in vitro. Specifically, combinations of the microbial pigment prodigiosin with metal nanoparticles showed a significant decrease in the IC50 values on both parasites (2.7 to 3.6 fold) without increase of cytotoxicity upon mammalian cells. The data may be useful for the microbial pigment based drug designing.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalParasitology International
Volume64
Issue number5
DOIs
StatePublished - 1 Oct 2015
Externally publishedYes

Keywords

  • Antimalarial
  • Plasmodium falciparum
  • Prodigiosin
  • Trypanosoma brucei gambiense
  • Violacein

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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