TY - JOUR
T1 - In vitro antiviral and antibacterial activity of commercial intravenous immunoglobulin preparations - A potential role for adjuvant intravenous immunoglobulin therapy in infectious diseases
AU - Krause, I.
AU - Wu, R.
AU - Sherer, Y.
AU - Patanik, M.
AU - Peter, J. B.
AU - Shoenfeld, Y.
PY - 2002/5/4
Y1 - 2002/5/4
N2 - The identification of specific antimicrobial activity of intravenous immunoglobulin (IVIG) preparations against particular microbial pathogens can assist in determining their therapeutic potential for specific infectious diseases. We analysed five different commercial IVIG preparations for the presence of antibodies directed against a large panel of viral, bacterial, fungal and parasitic pathogens. All IVIG batches contained high activity against herpesviruses types 1, 2, 6 and 7, as well as against varicella zoster virus, Epstein-Barr virus (EBV), measles, mumps, rubella and parvovirus B19. Some IVIG batches also had a significant activity against adenovirus and Saint Louis encephalitis virus. The IVIGs held high activity against several bacterial pathogens, including Mycoplasma pneumonia, Chlamydia pneumonia, Helicobacter pylori and tetanus. No activity was found against various parasitic and fungal pathogens. Our findings may provide further support for the use of IVIG for the prevention and treatment of infections caused by specific viral and bacterial pathogens.
AB - The identification of specific antimicrobial activity of intravenous immunoglobulin (IVIG) preparations against particular microbial pathogens can assist in determining their therapeutic potential for specific infectious diseases. We analysed five different commercial IVIG preparations for the presence of antibodies directed against a large panel of viral, bacterial, fungal and parasitic pathogens. All IVIG batches contained high activity against herpesviruses types 1, 2, 6 and 7, as well as against varicella zoster virus, Epstein-Barr virus (EBV), measles, mumps, rubella and parvovirus B19. Some IVIG batches also had a significant activity against adenovirus and Saint Louis encephalitis virus. The IVIGs held high activity against several bacterial pathogens, including Mycoplasma pneumonia, Chlamydia pneumonia, Helicobacter pylori and tetanus. No activity was found against various parasitic and fungal pathogens. Our findings may provide further support for the use of IVIG for the prevention and treatment of infections caused by specific viral and bacterial pathogens.
KW - Antibodies
KW - Infections
KW - Intravenous immunoglobulins
UR - http://www.scopus.com/inward/record.url?scp=0036228218&partnerID=8YFLogxK
U2 - 10.1046/j.1365-3148.2002.00360.x
DO - 10.1046/j.1365-3148.2002.00360.x
M3 - Article
AN - SCOPUS:0036228218
SN - 0958-7578
VL - 12
SP - 133
EP - 139
JO - Transfusion Medicine
JF - Transfusion Medicine
IS - 2
ER -