In vitro antiviral and antibacterial activity of commercial intravenous immunoglobulin preparations - A potential role for adjuvant intravenous immunoglobulin therapy in infectious diseases

I. Krause, R. Wu, Y. Sherer, M. Patanik, J. B. Peter, Y. Shoenfeld

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

The identification of specific antimicrobial activity of intravenous immunoglobulin (IVIG) preparations against particular microbial pathogens can assist in determining their therapeutic potential for specific infectious diseases. We analysed five different commercial IVIG preparations for the presence of antibodies directed against a large panel of viral, bacterial, fungal and parasitic pathogens. All IVIG batches contained high activity against herpesviruses types 1, 2, 6 and 7, as well as against varicella zoster virus, Epstein-Barr virus (EBV), measles, mumps, rubella and parvovirus B19. Some IVIG batches also had a significant activity against adenovirus and Saint Louis encephalitis virus. The IVIGs held high activity against several bacterial pathogens, including Mycoplasma pneumonia, Chlamydia pneumonia, Helicobacter pylori and tetanus. No activity was found against various parasitic and fungal pathogens. Our findings may provide further support for the use of IVIG for the prevention and treatment of infections caused by specific viral and bacterial pathogens.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalTransfusion Medicine
Volume12
Issue number2
DOIs
StatePublished - 4 May 2002
Externally publishedYes

Keywords

  • Antibodies
  • Infections
  • Intravenous immunoglobulins

ASJC Scopus subject areas

  • Hematology

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