In vitro fertilization surrogacy in rare coexisting Mayer-Rokitansky- Kuster-Hauser syndrome and triple X karyotype

Arieh Raziel, Shevach Friedler, Yariv Gidoni, Ido Ben-Ami, Deborah Strassburger, Raphael Ron-El

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Objective: To report the responses to IVF surrogacy attempts in a female with a heretofore never described combination of Mayer-Rokitansky-Kuster-Hauser (MRHK) syndrome and triple X karyotype. Design: Case report. Setting: Reproductive unit of a university-affiliated medical center. Patient(s): A 29-year-old female diagnosed as having both MRHK syndrome and a triple X (47XXX) karyotype. Intervention(s): Five cycles of IVF surrogacy. Main Outcome Measure(s): Recovery of oocytes after controlled ovarian stimulation. Result(s): A maximum of five oocytes were retrieved by percutaneous abdominal aspiration of a single subcostal left ovary. After five unsuccessful IVF trials due to low ovarian response attributed to her coexisting MRHK syndrome and triple X karyotype, the patient's choice was oocyte donation. Conclusion(s): An abnormal karyotype can coexist with MRKH syndrome, albeit very rarely, and probably accounts for a low ovarian response to attempts to achieve IVF surrogacy.

Original languageEnglish
Pages (from-to)1788.e11-1788.e13
JournalFertility and Sterility
Volume95
Issue number5
DOIs
StatePublished - 1 Jan 2011
Externally publishedYes

Keywords

  • MRKH syndrome
  • low ovarian response
  • primary amenorrhea
  • surrogacy
  • surrogate IVF
  • triple X karyotype
  • vaginal agenesis

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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