"In vitro" studies on the fate of diphenylhydantoin in uremia

Y. Herishanu; U. Eylath; R. Ilan

doi:10.1016/0304-3940(76)90031-8

"In vitro" studies on the fate of diphenylhydantoin in uremia

Y. Herishanu, U. Eylath, R. Ilan

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Abstract

"In vitro" studies were undertaken to evaluate the fate of DPH in blood of uremic patients. DPH incubated for 18 h at 37°C disappears from plasma in the presence of erythrocytes and more when the blood underwent hemolysis. This phenomenon was more pronounced in uremic blood. These findings suggest not only that DPH is absorbed onto the erythrocyte membrane, but also that it is bound by erythrocyte contents. It could be possible that, because of a low binding capacity of the albumin carrier in uremic blood, the drug penetrates more easily the erythrocyte membrane and is bound there. An intraery throcyte enzymatic metabolism of DPH is not excluded.

Original language	English
Pages (from-to)	97-101
Number of pages	5
Journal	Neuroscience Letters
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(76)90031-8
State	Published - 1 Jan 1976
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(76)90031-8

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abstract = "{"}In vitro{"} studies were undertaken to evaluate the fate of DPH in blood of uremic patients. DPH incubated for 18 h at 37°C disappears from plasma in the presence of erythrocytes and more when the blood underwent hemolysis. This phenomenon was more pronounced in uremic blood. These findings suggest not only that DPH is absorbed onto the erythrocyte membrane, but also that it is bound by erythrocyte contents. It could be possible that, because of a low binding capacity of the albumin carrier in uremic blood, the drug penetrates more easily the erythrocyte membrane and is bound there. An intraery throcyte enzymatic metabolism of DPH is not excluded.",

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AB - "In vitro" studies were undertaken to evaluate the fate of DPH in blood of uremic patients. DPH incubated for 18 h at 37°C disappears from plasma in the presence of erythrocytes and more when the blood underwent hemolysis. This phenomenon was more pronounced in uremic blood. These findings suggest not only that DPH is absorbed onto the erythrocyte membrane, but also that it is bound by erythrocyte contents. It could be possible that, because of a low binding capacity of the albumin carrier in uremic blood, the drug penetrates more easily the erythrocyte membrane and is bound there. An intraery throcyte enzymatic metabolism of DPH is not excluded.

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"In vitro" studies on the fate of diphenylhydantoin in uremia

Abstract

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