In vitro study of enhanced photodynamic cancer cell killing effect by nanometer-thick gold nanosheets

Ziyi Zhang; Dalong Ni; Fei Wang; Xin Yin; Shreya Goel; Lazarus N. German; Yizhan Wang; Jun Li; Weibo Cai; Xudong Wang

doi:10.1007/s12274-020-2990-7

In vitro study of enhanced photodynamic cancer cell killing effect by nanometer-thick gold nanosheets

Ziyi Zhang, Dalong Ni, Fei Wang, Xin Yin, Shreya Goel, Lazarus N. German, Yizhan Wang, Jun Li, Weibo Cai, Xudong Wang

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Photodynamic therapy (PDT) by near-infrared (NIR) irradiation is a promising technique for treating various cancers. Here, we reported the development of free-standing wafer-scale Au nanosheets (NSs) that exhibited an impressive PDT effect. The Au NSs were synthesized by ionic layer epitaxy at the air-water interface with a uniform thickness in the range from 2 to 8.5 nm. These Au NSs were found very effective in generating singlet oxygen under NIR irradiation. In vitro cellular study showed that the Au NSs had very low cytotoxicity and high PDT efficiency due to their uniform 2D morphology. Au NSs could kill cancer cells after 5 min NIR irradiation with little heat generation. This performance is comparable to using 10 times mass loading of Au nanoparticles (NPs). This work suggests that two-dimensional (2D) Au NSs could be a new type of biocompatible nanomaterial for PDT of cancer with an extraordinary photon conversion and cancer cell killing efficiency.[Figure not available: see fulltext.].

Original language	English
Pages (from-to)	3217-3223
Number of pages	7
Journal	Nano Research
Volume	13
Issue number	12
DOIs	https://doi.org/10.1007/s12274-020-2990-7
State	Published - 1 Dec 2020
Externally published	Yes

Keywords

cancer therapy
gold nanosheet
ionic layer epitaxy
photodynamic effect
surface plasmon

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
General Materials Science
Condensed Matter Physics
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12274-020-2990-7

Cite this

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title = "In vitro study of enhanced photodynamic cancer cell killing effect by nanometer-thick gold nanosheets",

abstract = "Photodynamic therapy (PDT) by near-infrared (NIR) irradiation is a promising technique for treating various cancers. Here, we reported the development of free-standing wafer-scale Au nanosheets (NSs) that exhibited an impressive PDT effect. The Au NSs were synthesized by ionic layer epitaxy at the air-water interface with a uniform thickness in the range from 2 to 8.5 nm. These Au NSs were found very effective in generating singlet oxygen under NIR irradiation. In vitro cellular study showed that the Au NSs had very low cytotoxicity and high PDT efficiency due to their uniform 2D morphology. Au NSs could kill cancer cells after 5 min NIR irradiation with little heat generation. This performance is comparable to using 10 times mass loading of Au nanoparticles (NPs). This work suggests that two-dimensional (2D) Au NSs could be a new type of biocompatible nanomaterial for PDT of cancer with an extraordinary photon conversion and cancer cell killing efficiency.[Figure not available: see fulltext.].",

keywords = "cancer therapy, gold nanosheet, ionic layer epitaxy, photodynamic effect, surface plasmon",

author = "Ziyi Zhang and Dalong Ni and Fei Wang and Xin Yin and Shreya Goel and German, {Lazarus N.} and Yizhan Wang and Jun Li and Weibo Cai and Xudong Wang",

note = "Publisher Copyright: {\textcopyright} 2020, Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2020",

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doi = "10.1007/s12274-020-2990-7",

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TY - JOUR

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AU - Zhang, Ziyi

AU - Ni, Dalong

AU - Wang, Fei

AU - Yin, Xin

AU - Goel, Shreya

AU - German, Lazarus N.

AU - Wang, Yizhan

AU - Li, Jun

AU - Cai, Weibo

AU - Wang, Xudong

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Photodynamic therapy (PDT) by near-infrared (NIR) irradiation is a promising technique for treating various cancers. Here, we reported the development of free-standing wafer-scale Au nanosheets (NSs) that exhibited an impressive PDT effect. The Au NSs were synthesized by ionic layer epitaxy at the air-water interface with a uniform thickness in the range from 2 to 8.5 nm. These Au NSs were found very effective in generating singlet oxygen under NIR irradiation. In vitro cellular study showed that the Au NSs had very low cytotoxicity and high PDT efficiency due to their uniform 2D morphology. Au NSs could kill cancer cells after 5 min NIR irradiation with little heat generation. This performance is comparable to using 10 times mass loading of Au nanoparticles (NPs). This work suggests that two-dimensional (2D) Au NSs could be a new type of biocompatible nanomaterial for PDT of cancer with an extraordinary photon conversion and cancer cell killing efficiency.[Figure not available: see fulltext.].

AB - Photodynamic therapy (PDT) by near-infrared (NIR) irradiation is a promising technique for treating various cancers. Here, we reported the development of free-standing wafer-scale Au nanosheets (NSs) that exhibited an impressive PDT effect. The Au NSs were synthesized by ionic layer epitaxy at the air-water interface with a uniform thickness in the range from 2 to 8.5 nm. These Au NSs were found very effective in generating singlet oxygen under NIR irradiation. In vitro cellular study showed that the Au NSs had very low cytotoxicity and high PDT efficiency due to their uniform 2D morphology. Au NSs could kill cancer cells after 5 min NIR irradiation with little heat generation. This performance is comparable to using 10 times mass loading of Au nanoparticles (NPs). This work suggests that two-dimensional (2D) Au NSs could be a new type of biocompatible nanomaterial for PDT of cancer with an extraordinary photon conversion and cancer cell killing efficiency.[Figure not available: see fulltext.].

KW - cancer therapy

KW - gold nanosheet

KW - ionic layer epitaxy

KW - photodynamic effect

KW - surface plasmon

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DO - 10.1007/s12274-020-2990-7

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JF - Nano Research

IS - 12

ER -

In vitro study of enhanced photodynamic cancer cell killing effect by nanometer-thick gold nanosheets

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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