In vivo burn diagnosis by camera-phone diffuse reflectance laser speckle detection

S. Ragol, I. Remer, Y. Shoham, S. Hazan, U. Willenz, I. Sinelnikov, V. Dronov, L. Rosenberg, A. Bilenca

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Burn diagnosis using laser speckle light typically employs widefield illumination of the burn region to produce two-dimensional speckle patterns from light backscattered from the entire irradiated tissue volume. Analysis of speckle contrast in these time-integrated patterns can then provide information on burn severity. Here, by contrast, we use point illumination to generate diffuse reflectance laser speckle patterns of the burn. By examining spatiotemporal fluctuations in these time-integrated patterns along the radial direction from the incident point beam, we show the ability to distinguish partial-thickness burns in a porcine model in vivo within the first 24 hours post-burn. Furthermore, our findings suggest that time-integrated diffuse reflectance laser speckle can be useful for monitoring burn healing over time post-burn. Unlike conventional diffuse reflectance laser speckle detection systems that utilize scientific or industrial-grade cameras, our system is designed with a camera-phone, demonstrating the potential for burn diagnosis with a simple imager.

Original languageEnglish
Pages (from-to)225-237
Number of pages13
JournalBiomedical Optics Express
Volume7
Issue number1
DOIs
StatePublished - 23 Dec 2015

Keywords

  • Medical optics instrumentation
  • Optical diagnostics for medicine
  • Speckle

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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