In vivo cyclic AMP responses in rat brain are not modified by chronic electroconvulsive shock

Eitan Gur; Elisha Berman; Bernard Lerer; Michael E. Newman

doi:10.1016/S0924-977X(97)00399-4

In vivo cyclic AMP responses in rat brain are not modified by chronic electroconvulsive shock

Eitan Gur, Elisha Berman, Bernard Lerer, Michael E. Newman

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

In vivo microdialysis was used to determine the effects of chronic electroniconvulsive shock (ECS), given daily for 10 days, on the cyclic AMP (cAMP) responses to noradrenaline (NA) and to forskolin in the cortex of freely-moving conscious rats. Microdialysis probes were inserted on the final day of ECS administration, and cAMP responses measured the following day. Chronic ECS did not modify the responses to either NA or forskolin. These results differ markedly from those previously obtained with incubated slices of rat brain. It is concluded that care is needed in interpreting results obtained by either ex vivo or in vitro methods.

Original language	English
Pages (from-to)	189-193
Number of pages	5
Journal	European Neuropsychopharmacology
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/S0924-977X(97)00399-4
State	Published - 1 Aug 1997
Externally published	Yes

Keywords

Cortex
Cyclic AMP
Electroconvulsive shock
Forskolin
Microdialysis
Noradrenaline
Rat

ASJC Scopus subject areas

Pharmacology
Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry
Pharmacology (medical)

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title = "In vivo cyclic AMP responses in rat brain are not modified by chronic electroconvulsive shock",

abstract = "In vivo microdialysis was used to determine the effects of chronic electroniconvulsive shock (ECS), given daily for 10 days, on the cyclic AMP (cAMP) responses to noradrenaline (NA) and to forskolin in the cortex of freely-moving conscious rats. Microdialysis probes were inserted on the final day of ECS administration, and cAMP responses measured the following day. Chronic ECS did not modify the responses to either NA or forskolin. These results differ markedly from those previously obtained with incubated slices of rat brain. It is concluded that care is needed in interpreting results obtained by either ex vivo or in vitro methods.",

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T1 - In vivo cyclic AMP responses in rat brain are not modified by chronic electroconvulsive shock

AU - Gur, Eitan

AU - Berman, Elisha

AU - Lerer, Bernard

AU - Newman, Michael E.

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Y1 - 1997/8/1

N2 - In vivo microdialysis was used to determine the effects of chronic electroniconvulsive shock (ECS), given daily for 10 days, on the cyclic AMP (cAMP) responses to noradrenaline (NA) and to forskolin in the cortex of freely-moving conscious rats. Microdialysis probes were inserted on the final day of ECS administration, and cAMP responses measured the following day. Chronic ECS did not modify the responses to either NA or forskolin. These results differ markedly from those previously obtained with incubated slices of rat brain. It is concluded that care is needed in interpreting results obtained by either ex vivo or in vitro methods.

AB - In vivo microdialysis was used to determine the effects of chronic electroniconvulsive shock (ECS), given daily for 10 days, on the cyclic AMP (cAMP) responses to noradrenaline (NA) and to forskolin in the cortex of freely-moving conscious rats. Microdialysis probes were inserted on the final day of ECS administration, and cAMP responses measured the following day. Chronic ECS did not modify the responses to either NA or forskolin. These results differ markedly from those previously obtained with incubated slices of rat brain. It is concluded that care is needed in interpreting results obtained by either ex vivo or in vitro methods.

KW - Cortex

KW - Cyclic AMP

KW - Electroconvulsive shock

KW - Forskolin

KW - Microdialysis

KW - Noradrenaline

KW - Rat

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AN - SCOPUS:0030871698

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ER -

In vivo cyclic AMP responses in rat brain are not modified by chronic electroconvulsive shock

Abstract

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