TY - JOUR
T1 - Incidence and initial disease course of inflammatory bowel diseases in 2011 in Europe and Australia
T2 - Results of the 2011 ECCO-EpiCom inception cohort
AU - For the EpiCom-group
AU - Vegh, Z.
AU - Burisch, J.
AU - Pedersen, N.
AU - Kaimakliotis, I.
AU - Duricova, D.
AU - Bortlik, M.
AU - Avnstrøm, S.
AU - Vinding, K. Kofod
AU - Olsen, J.
AU - Nielsen, K. R.
AU - Katsanos, K. H.
AU - Tsianos, E. V.
AU - Lakatos, L.
AU - Schwartz, D.
AU - Odes, S.
AU - Lupinacci, G.
AU - De Padova, A.
AU - Jonaitis, L.
AU - Kupcinskas, L.
AU - Turcan, S.
AU - Tighineanu, O.
AU - Mihu, I.
AU - Barros, L. F.
AU - Magro, F.
AU - Lazar, D.
AU - Goldis, A.
AU - Fernandez, A.
AU - Hernandez, V.
AU - Niewiadomski, O.
AU - Bell, S.
AU - Langholz, E.
AU - Munkholm, P.
AU - Lakatos, P. L.
N1 - Funding Information:
Unrestricted grant support has been received from the Danish Colitis Crohn Patients Organization (CCF), the Vibeke Binder and Povl Riis' Foundation, the Scientific Council at Herlev Hospital, the Sigrid Rigmor Moran Foundation, Aage and Johanne Louis-Hansens Foundation, the Munkholm Foundation, the C.C. Klestrup and Henriette Klestrup Foundation, the Knud and Dagny Gad Andresens Foundation, the Else and Mogens Wedell-Wedellsborgs Foundation, the Direktør Jacob Madsen and Olga Madsens Foundation, ScanVet, the Torben og Alice Frimodt Foundation, Lægernes forsikringsforening af 1891, Bengt Ihre's foundation, Nanna Svartz' foundation, Örebro University Hospital Research Foundation, Örebro County Research Foundation, The Swedish Foundation for Gastrointestinal research, The Swedish Research Council, The Swedish Society of Medicine, the Research Council of South-East Sweden, the County Council of Östergötland, The Swedish Organization for the study of Inflammatory bowel disease, International Organization of Inflammatory Bowel Diseases (IOIBD), the Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital (Grant 9P008), and ECCO. The study sponsors have no contribution in the study design, analysis, interpretation of data and publication.
Publisher Copyright:
© 2014 European Crohn's and Colitis Organisation.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Background and aims: The aim of the present study was to validate the IBD (inflammatory bowel diseases) incidence reported in the 2010 ECCO-EpiCom (European Crohn's and Colitis Organization-Epidemiological Committee) inception cohort by including a second independent inception cohort from participating centers in 2011 and an Australian center to investigate whether there is a difference in the incidence of IBD between Eastern and Western European countries and Australia. Methods: Fourteen centers from 5 Eastern and 9 Western European countries and one center from Australia participated in the ECCO-EpiCom 2011 inception cohort. Patients' data regarding disease type, socio-demographic factors, extraintestinal manifestations and therapy were entered into the Web-based EpiCom database, www.ecco-epicom.eu. Results: A total of 711 adult patients were diagnosed during the inclusion year 2011, 178 (25%) from Eastern, 461 (65%) from Western Europe and 72 (10%) from Australia; 259 (37%) patients were diagnosed with Crohn's disease, 380 (53%) with ulcerative colitis and 72 (10%) with IBD unclassified. The mean annual incidence rate for IBD was 11.3/100,000 in Eastern Europe, 14.0/100,000 in Western Europe and 30.3/100,000 in Australia. Significantly more patients were diagnosed with complicated disease at diagnosis in Eastern Europe compared to Western Europe (43% vs. 27%, p=. 0.02). Conclusion: Incidence rates, disease phenotype and initial treatment characteristics in the 2011 ECCO-EpiCom cohort were not significantly different from that reported in the 2010 cohort.
AB - Background and aims: The aim of the present study was to validate the IBD (inflammatory bowel diseases) incidence reported in the 2010 ECCO-EpiCom (European Crohn's and Colitis Organization-Epidemiological Committee) inception cohort by including a second independent inception cohort from participating centers in 2011 and an Australian center to investigate whether there is a difference in the incidence of IBD between Eastern and Western European countries and Australia. Methods: Fourteen centers from 5 Eastern and 9 Western European countries and one center from Australia participated in the ECCO-EpiCom 2011 inception cohort. Patients' data regarding disease type, socio-demographic factors, extraintestinal manifestations and therapy were entered into the Web-based EpiCom database, www.ecco-epicom.eu. Results: A total of 711 adult patients were diagnosed during the inclusion year 2011, 178 (25%) from Eastern, 461 (65%) from Western Europe and 72 (10%) from Australia; 259 (37%) patients were diagnosed with Crohn's disease, 380 (53%) with ulcerative colitis and 72 (10%) with IBD unclassified. The mean annual incidence rate for IBD was 11.3/100,000 in Eastern Europe, 14.0/100,000 in Western Europe and 30.3/100,000 in Australia. Significantly more patients were diagnosed with complicated disease at diagnosis in Eastern Europe compared to Western Europe (43% vs. 27%, p=. 0.02). Conclusion: Incidence rates, disease phenotype and initial treatment characteristics in the 2011 ECCO-EpiCom cohort were not significantly different from that reported in the 2010 cohort.
KW - Inception cohort
KW - Incidence
KW - Inflammatory bowel diseases
UR - http://www.scopus.com/inward/record.url?scp=84927786121&partnerID=8YFLogxK
U2 - 10.1016/j.crohns.2014.06.004
DO - 10.1016/j.crohns.2014.06.004
M3 - Article
AN - SCOPUS:84927786121
SN - 1873-9946
VL - 8
SP - 1506
EP - 1515
JO - Journal of Crohn's and Colitis
JF - Journal of Crohn's and Colitis
IS - 11
ER -