Incidental detection of metastatic malignant melanoma on 68Ga-prostate-specific membrane antigen PET/CT imaging: Correlative imaging with FDG PET/CT and review of the literature

Reut Anconina; Nir Hod; Daniel Levin; Dina Ezroh Kazap; Sophie Lantsberg

doi:10.1097/RLU.0000000000001959

Incidental detection of metastatic malignant melanoma on ⁶⁸Ga-prostate-specific membrane antigen PET/CT imaging: Correlative imaging with FDG PET/CT and review of the literature

Reut Anconina, Nir Hod, Daniel Levin, Dina Ezroh Kazap, Sophie Lantsberg

Medical School for International Health

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

An 80-year-old man with suspected recurrent prostate carcinoma underwent ⁶⁸Ga-PSMA PET/CT, which showed enlarged axillary lymph nodes with intensely increased ⁶⁸Ga-PSMA uptake, an atypical site for prostate cancer metastasis. Fine-needle aspiration biopsy revealed metastatic malignant melanoma. FDG PET/CT revealed congruent intense FDG uptake. Therefore, malignant melanoma should be included in the list of malignancies that can be seen positive on ⁶⁸Ga-PSMA PET/CT. In unclear ⁶⁸Ga-PSMA PET-positive lesions, further clarification with other imaging techniques or biopsy is mandatory to avoid scan misinterpretation. Review of the literature revealed other non-prostate cancer causes of elevated PSMA uptake classified into neoplastic and nonneoplastic conditions.

Original language	English
Pages (from-to)	204-206
Number of pages	3
Journal	Clinical Nuclear Medicine
Volume	43
Issue number	3
DOIs	https://doi.org/10.1097/RLU.0000000000001959
State	Published - 1 Mar 2018

Keywords

FDG PET/CT
Ga-PSMA PET/CT
Incidentaloma
Malignant melanoma

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/RLU.0000000000001959

Cite this

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title = "Incidental detection of metastatic malignant melanoma on 68Ga-prostate-specific membrane antigen PET/CT imaging: Correlative imaging with FDG PET/CT and review of the literature",

abstract = "An 80-year-old man with suspected recurrent prostate carcinoma underwent 68Ga-PSMA PET/CT, which showed enlarged axillary lymph nodes with intensely increased 68Ga-PSMA uptake, an atypical site for prostate cancer metastasis. Fine-needle aspiration biopsy revealed metastatic malignant melanoma. FDG PET/CT revealed congruent intense FDG uptake. Therefore, malignant melanoma should be included in the list of malignancies that can be seen positive on 68Ga-PSMA PET/CT. In unclear 68Ga-PSMA PET-positive lesions, further clarification with other imaging techniques or biopsy is mandatory to avoid scan misinterpretation. Review of the literature revealed other non-prostate cancer causes of elevated PSMA uptake classified into neoplastic and nonneoplastic conditions.",

keywords = "FDG PET/CT, Ga-PSMA PET/CT, Incidentaloma, Malignant melanoma",

author = "Reut Anconina and Nir Hod and Daniel Levin and Kazap, {Dina Ezroh} and Sophie Lantsberg",

year = "2018",

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doi = "10.1097/RLU.0000000000001959",

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TY - JOUR

T1 - Incidental detection of metastatic malignant melanoma on 68Ga-prostate-specific membrane antigen PET/CT imaging

T2 - Correlative imaging with FDG PET/CT and review of the literature

AU - Anconina, Reut

AU - Hod, Nir

AU - Levin, Daniel

AU - Kazap, Dina Ezroh

AU - Lantsberg, Sophie

PY - 2018/3/1

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N2 - An 80-year-old man with suspected recurrent prostate carcinoma underwent 68Ga-PSMA PET/CT, which showed enlarged axillary lymph nodes with intensely increased 68Ga-PSMA uptake, an atypical site for prostate cancer metastasis. Fine-needle aspiration biopsy revealed metastatic malignant melanoma. FDG PET/CT revealed congruent intense FDG uptake. Therefore, malignant melanoma should be included in the list of malignancies that can be seen positive on 68Ga-PSMA PET/CT. In unclear 68Ga-PSMA PET-positive lesions, further clarification with other imaging techniques or biopsy is mandatory to avoid scan misinterpretation. Review of the literature revealed other non-prostate cancer causes of elevated PSMA uptake classified into neoplastic and nonneoplastic conditions.

AB - An 80-year-old man with suspected recurrent prostate carcinoma underwent 68Ga-PSMA PET/CT, which showed enlarged axillary lymph nodes with intensely increased 68Ga-PSMA uptake, an atypical site for prostate cancer metastasis. Fine-needle aspiration biopsy revealed metastatic malignant melanoma. FDG PET/CT revealed congruent intense FDG uptake. Therefore, malignant melanoma should be included in the list of malignancies that can be seen positive on 68Ga-PSMA PET/CT. In unclear 68Ga-PSMA PET-positive lesions, further clarification with other imaging techniques or biopsy is mandatory to avoid scan misinterpretation. Review of the literature revealed other non-prostate cancer causes of elevated PSMA uptake classified into neoplastic and nonneoplastic conditions.

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