XIncisive Imaging and Computation for Cellular mysteries: Lessons from Abscission

Natalie Elia, Carolyn Ott, Jennifer Lippincott-Schwartz

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

The final cleavage event that terminates cell division, abscission of the small, dense intercellular bridge, has been particularly challenging to resolve. Here, we describe imaging innovations that helped answer long-standing questions about the mechanism of abscission. We further explain how computational modeling of high-resolution data was employed to test hypotheses and generate additional insights. We present the model that emerges from application of these complimentary approaches. Similar experimental strategies will undoubtedly reveal exciting details about other underresolved cellular structures.

Original languageEnglish
Pages (from-to)X1220-1231
JournalCell
Volume155
Issue number6
DOIs
StatePublished - 5 Dec 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)

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