Increase CCR5 expression with decreased β chemokine secretion in Ethiopians: Relevance to AIDS in Africa

Alexander Kalinkovich, Ziva Weisman, Qibin Leng, Gadi Borkow, Miguel Stein, Zalman Greenberg, Sofia Zlotnikov, Sara Eitan, Zvi Bentwich

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Objective: This study was undertaken to determine the contribution of HIV co-receptors and β chemokine secretion to the increased susceptibility for human immunodeficiency virus (HIV) infection of peripheral blood mononuclear cells (PBMC) obtained from HIV-seronegative Ethiopian immigrants in Israel (ETH). Study Design: Immune activation markers and HIV co-receptor expression on lymphocytes and monocytes, and β chemokine secretion by CD8+ cells, were compared between ETH and non-Ethiopian Israeli (IS) HIV-negative individuals. Results: The percentage of lymphocytes and monocytes expressing CCR5 was 1.6 and 3.0 times higher in ETH (n = 83) than in IS (n = 45), respectively (P < .001), whereas RANTES and MIP-1α secretion was 0.5 and 0.7 times lower (P < .01 and P < .05). The percentage of CCR5-expressing cells and RANTES secretion were inversely correlated (r = -0.7; P < .002). No differences were found in the proportion of CXCR4-expressing cells. No correlation between CCR5 expression and cell activation profile in the whole ETH population was found. However, in highly activated individuals (HLA- DR/CD3 >7%), a significant decrease in CCR5 expression was observed. Conclusions: An increased proportion of CCR5-expressing cells with decreased β chemokine secretion observed in ETH may account for the increased susceptibility to HIV infection of cells obtained from this group. These findings may partly explain the higher susceptibility for HIV infection in Africa and thus the rapid spread of acquired immunodeficiency syndrome (AIDS) in that continent. (C) Lippincott Williams and Wilkins, Inc.

Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalJournal of Human Virology
Volume2
Issue number5
StatePublished - 1 Sep 1999
Externally publishedYes

Keywords

  • Africa
  • Chemokine receptors
  • Chemokines
  • HIV infection
  • Susceptibility

Fingerprint

Dive into the research topics of 'Increase CCR5 expression with decreased β chemokine secretion in Ethiopians: Relevance to AIDS in Africa'. Together they form a unique fingerprint.

Cite this