Increase in rat intestinal permeability to endotoxin during hyperthermia

Y. Shapiro, M. Alkan, Y. Epstein, F. Newman, A. Magazanik

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


Victims of heat stroke exhibit several clinical features which are also encountered in endotoxaemia. In order to investigate these similarities hyperthermic rats were used to explore the possibility that high body temperature results in increased permeability of intestinal wall to endotoxin. 125I endotoxin was introduced into intestinal segments taken from non-heat exposed rats. The segments were then incubated at 37‡ C or 45‡ C. Intestinal segments from heat stressed rats were similarly prepared and incubated at 37‡ C. Leakage of endotoxin from segments taken from heat stressed rats was three times greater than from those from non-heat stressed rats, as were the segments from non-heat stressed rats which were incubated at 45‡ C. These results indicate that the intestinal membrane is damaged by heat and that an increase in outward leakage of microbial endotoxins from the gut then occurs. This might contribute to the pathophysiological picture of heatstroke.

Original languageEnglish
Pages (from-to)410-412
Number of pages3
JournalEuropean Journal of Applied Physiology and Occupational Physiology
Issue number4
StatePublished - 1 Aug 1986


  • Endotoxin
  • Hyperthermia

ASJC Scopus subject areas

  • Physiology
  • Public Health, Environmental and Occupational Health


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