@article{7bd3b779614e474fa7a4e09b8f3c0c9c,
title = "Increased amniotic fluid leukotriene C4 concentration in term human parturition",
abstract = "The purpose of this study was to determine whether parturition is associated with changes in the amniotic fluid concentration of leukotriene C4, an arachidonate lipoxygenase metabolite. Amniotic fluid was collected from 36 women not in labor and from 30 women in active labor with cervical dilation of ≥6 cm. The concentration of leukotriene C4 was determined by radioimmunoassay. The median amniotic fluid concentration of leukotriene C4 was greater in laboring women than in nonlaboring women: 121 pg/ml (range, 52 to 261 pg/ml) versus 73.5 pg/ml (range, 6 to 249 pg/ml), respectively (p = 0.0008). These data are consistent with activation of the lipoxygenase pathway during spontaneous parturition at term.",
keywords = "Leukotriene C, amniotic fluid, arachidonate lipoxygenase products, parturition",
author = "Roberto Romero and Wu, {Ying King} and Moshe Mazor and Hobbins, {John C.} and Mitchell, {Murray D.}",
note = "Funding Information: From the Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven,{"} and Department of Obstetrics and Gynecology, Michael Reese Hospital, Chicago.' Supported by a grant from the Walter Scott Foundation for Medical Research. Dr. Romero is a recipient of a Physician Scientist Award grant from the National Institute of Child Health and Human Development. Funding Information: From the Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, and the Division of Perinatal Medicine, Department of Reproductive Medicine, University of California, San Diego. This study was supported by grants from the Walter Scott Foundation for Medical Research and National Institutes of Health grant HD 20747. Presented at the Eighth Annual Meeting of the Society of Perinatal Obstetricians, Las Vegas, Nevada, February 4-6, 1988. Reprint requests: Roberto Romero, MD, Yale University School of Medicine, Department of Obstetrics and Gynecology, P.O. Box 3333, New Haven, CT 06510. *Recipient of a Physician Scientist Award from the National Institutes of Health.",
year = "1988",
month = jan,
day = "1",
doi = "10.1016/S0002-9378(88)80028-0",
language = "English",
volume = "159",
pages = "655--657",
journal = "American Journal of Obstetrics and Gynecology ",
issn = "0002-9378",
publisher = "Elsevier Inc.",
number = "3",
}