Increased arachidonate in lipids after administration to man: Effects on prostaglandin biosynthesis

Hannsjörg W. Seyberth, Oswald Oelz, Tom Kennedy, Brian J. Sweetman, Abraham Danon, Jürgen C. Frlich, Murray Heimberg, John A. Oates

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Abstract

Ethyl arachidonate was administered orally to 4 healthy male volunteers in a dose of 6 gm daily for a 2 to 3 wk period after a 10-day control period. The increased intake of this precursor of the dienoic prostaglandins resulted in significant increases in the relative and absolute amount of arachidonate in plasma triglycerides, phospholipids, and cholesteryl esters. Similar changes in lipid composition were noted in platelets. The excretion of 7α-hydroxy-5,11-diketotetranorprostane-1,16-dioic acid, the major urinary metabolite of E prostaglandins in man, was increased by an average of 47% in 3 of the 4 volunteers. Platelet reactivity was assessed by determining the threshold concentration of adenosine diphosphate (ADP) necessary to induce secondary, irreversible aggregation of platelet-rich plasma. This threshold concentration dropped significantly in all volunteers (10% to 60% of control values). It is concluded that the biosynthesis and function of prostaglandins can be augmented in man by oral administration of an esterified precursor fatty acid.

Original languageEnglish
Pages (from-to)521-529
Number of pages9
JournalClinical Pharmacology and Therapeutics
Volume18
Issue number5 PART 1
DOIs
StatePublished - 1 Jan 1975
Externally publishedYes

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