Increased axonal excitability during exposure to hyperbaric oxygen

N. Bitterman, Y. Grossman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The effect of high oxygen pressure on neural function was studied in the isolated nervous system of the cockroach. Intracellular and extracellular action potentials were recorded from single giant axons during exposure to 7 ATA (atmosphere absolute) (1 ATA = 0.1 MPa) of oxygen. Axonal excitability was measured as changes in stimulus strength-duration relationship. Initially, a transient increase in the rheobase current was observed followed by a significant decline to 75% of air control values. This decrease was accompanied by a parallel increase in the membrane time constant. The results demonstrate that hyperbaric oxygen increases axonal excitability. Such changes are consistent with the epileptogenic properties of high oxygen pressure.

Original languageEnglish
Pages (from-to)2044-2047
Number of pages4
JournalCanadian Journal of Physiology and Pharmacology
Issue number10
StatePublished - 1 Jan 1987
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)


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