Increased cerebrospinal fluid glutamine levels in depressed patients

Joseph Levine, Kanagasabai Panchalingam, Avraham Rapoport, Samuel Gershon, Richard J. McClure, Jay W. Pettegrew

    Research output: Contribution to journalArticlepeer-review

    198 Scopus citations

    Abstract

    Background: There is increasing evidence for an association between alterations of brain glutamatergic neurotransmission and the pathophysiology of affective disorders. Methods: We studied the association between cerebrospinal fluid (CSF) metabolites, including glutamine, in unipolar and bipolar depressed patients versus control subjects using a proton magnetic resonance spectroscopy technique. Cerebrospinal fluid samples were obtained from 18 hospitalized patients with acute unmedicated severe depression without medical problems and compared with those of 22 control subjects. Results: Compared with the control group, the depressed patient group had significantly higher CSF glutamine concentrations, which correlated positively with CSF magnesium levels. Conclusions: These findings suggest an abnormality of the brain glial-neuronal glutamine/glutamate cycle associated with N-methyl-D-aspartate receptor systems in patients with depression. Copyright (C) 2000 Society of Biological Psychiatry.

    Original languageEnglish
    Pages (from-to)586-593
    Number of pages8
    JournalBiological Psychiatry
    Volume47
    Issue number7
    DOIs
    StatePublished - 1 Apr 2000

    Keywords

    • Creatine
    • Glutamine
    • H MRS
    • Major depression
    • β-hydroxybutyrate

    ASJC Scopus subject areas

    • Biological Psychiatry

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