Increased High-Molecular-Weight Thyrotropin with Impaired Biologic Activity in a Euthyroid Man

Irving M. Spitz; Derek le Roith; Harry Hirsch; Pierre Carayon; Fredrika Pekonen; Yair Liel; Reuven Sobel; Zamir Chorer; Bruce Weintraub; Bruce Weintraub

doi:10.1056/NEJM198101293040506

Increased High-Molecular-Weight Thyrotropin with Impaired Biologic Activity in a Euthyroid Man

Irving M. Spitz, Derek le Roith, Harry Hirsch, Pierre Carayon, Fredrika Pekonen, Yair Liel, Reuven Sobel, Zamir Chorer, Bruce Weintraub, Bruce Weintraub

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Abstract

CIRCULATING high-molecular-weight forms of many polypeptide hormones have been described, but there have been few reports of their occurrence as the predominant forms of glycoprotein hormones.¹ ² ³ ⁴ ⁵ ⁶ ⁷ ⁸ This paper describes the presence, in a healthy young man, of a high-molecular-weight species of immunoreactive thyrotropin (TSH), which bound normally to the TSH receptor but showed decreased stimulation of the adenylate cyclase of human thyroid membranes. Case Report During studies of 30 to 40 normal medical-student volunteers, a healthy 29-year-old man was discovered to have an elevated serum TSH level in a double-antibody radioimmunoassay. His history was noncontributory, and there was no family.

Original language	English
Pages (from-to)	278-282
Number of pages	5
Journal	New England Journal of Medicine
Volume	304
Issue number	5
DOIs	https://doi.org/10.1056/NEJM198101293040506
State	Published - 29 Jan 1981
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "Increased High-Molecular-Weight Thyrotropin with Impaired Biologic Activity in a Euthyroid Man",

abstract = "CIRCULATING high-molecular-weight forms of many polypeptide hormones have been described, but there have been few reports of their occurrence as the predominant forms of glycoprotein hormones.1 2 3 4 5 6 7 8 This paper describes the presence, in a healthy young man, of a high-molecular-weight species of immunoreactive thyrotropin (TSH), which bound normally to the TSH receptor but showed decreased stimulation of the adenylate cyclase of human thyroid membranes. Case Report During studies of 30 to 40 normal medical-student volunteers, a healthy 29-year-old man was discovered to have an elevated serum TSH level in a double-antibody radioimmunoassay. His history was noncontributory, and there was no family.",

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language = "English",

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AU - Spitz, Irving M.

AU - le Roith, Derek

AU - Hirsch, Harry

AU - Carayon, Pierre

AU - Pekonen, Fredrika

AU - Liel, Yair

AU - Sobel, Reuven

AU - Chorer, Zamir

AU - Weintraub, Bruce

PY - 1981/1/29

Y1 - 1981/1/29

N2 - CIRCULATING high-molecular-weight forms of many polypeptide hormones have been described, but there have been few reports of their occurrence as the predominant forms of glycoprotein hormones.1 2 3 4 5 6 7 8 This paper describes the presence, in a healthy young man, of a high-molecular-weight species of immunoreactive thyrotropin (TSH), which bound normally to the TSH receptor but showed decreased stimulation of the adenylate cyclase of human thyroid membranes. Case Report During studies of 30 to 40 normal medical-student volunteers, a healthy 29-year-old man was discovered to have an elevated serum TSH level in a double-antibody radioimmunoassay. His history was noncontributory, and there was no family.

AB - CIRCULATING high-molecular-weight forms of many polypeptide hormones have been described, but there have been few reports of their occurrence as the predominant forms of glycoprotein hormones.1 2 3 4 5 6 7 8 This paper describes the presence, in a healthy young man, of a high-molecular-weight species of immunoreactive thyrotropin (TSH), which bound normally to the TSH receptor but showed decreased stimulation of the adenylate cyclase of human thyroid membranes. Case Report During studies of 30 to 40 normal medical-student volunteers, a healthy 29-year-old man was discovered to have an elevated serum TSH level in a double-antibody radioimmunoassay. His history was noncontributory, and there was no family.

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Increased High-Molecular-Weight Thyrotropin with Impaired Biologic Activity in a Euthyroid Man

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