TY - JOUR
T1 - Increased Incidence of Childhood Lymphoma in Children with a History of Small for Gestational Age at Birth
AU - Kessous, Roy
AU - Sheiner, Eyal
AU - Rosen, Guy Beck
AU - Kapelushnik, Joseph
AU - Wainstock, Tamar
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2022/2/8
Y1 - 2022/2/8
N2 - OBJECTIVE: The aim of this study was to evaluate whether children that were born small for gestational age (SGA) have an increased risk for childhood neoplasm.STUDY DESIGN: A population-based cohort analysis comparing the risk for long-term childhood neoplasms (benign and malignant) in children that were born SGA vs. those that were appropriate for gestational age (AGA), between the years1991-2014. Childhood neoplasms were predefined based on ICD-9 codes, as recorded in the hospital medical files. Kaplan-Meier survival curves were constructed to compare cumulative oncological morbidity in both groups over time. Cox proportional hazards model was used to control for confounders.RESULTS: During the study period 231,973 infants met the inclusion criteria; out of those 10,998 were born with a diagnosis of SGA. Children that were SGA at birth had higher incidence of lymphoma (OR 2.50, 95% CI 1.06-5.82; p value = 0.036). In addition, cumulative incidence over time of total childhood lymphoma was significantly higher in SGA children (Log Rank = 0.030). In a Cox regression model controlling for other perinatal confounders; SGA at birth remained independently associated with an increased risk for childhood lymphoma (adjusted HR 2.41, 95% CI 1.03-5.56, p value = 0.043).CONCLUSION: Being delivered SGA is associated with an increased long-term risk for childhood malignancy and specifically lymphoma.
AB - OBJECTIVE: The aim of this study was to evaluate whether children that were born small for gestational age (SGA) have an increased risk for childhood neoplasm.STUDY DESIGN: A population-based cohort analysis comparing the risk for long-term childhood neoplasms (benign and malignant) in children that were born SGA vs. those that were appropriate for gestational age (AGA), between the years1991-2014. Childhood neoplasms were predefined based on ICD-9 codes, as recorded in the hospital medical files. Kaplan-Meier survival curves were constructed to compare cumulative oncological morbidity in both groups over time. Cox proportional hazards model was used to control for confounders.RESULTS: During the study period 231,973 infants met the inclusion criteria; out of those 10,998 were born with a diagnosis of SGA. Children that were SGA at birth had higher incidence of lymphoma (OR 2.50, 95% CI 1.06-5.82; p value = 0.036). In addition, cumulative incidence over time of total childhood lymphoma was significantly higher in SGA children (Log Rank = 0.030). In a Cox regression model controlling for other perinatal confounders; SGA at birth remained independently associated with an increased risk for childhood lymphoma (adjusted HR 2.41, 95% CI 1.03-5.56, p value = 0.043).CONCLUSION: Being delivered SGA is associated with an increased long-term risk for childhood malignancy and specifically lymphoma.
KW - Childhood malignancy
KW - Lymphoma
KW - Small for gestational age
UR - http://www.scopus.com/inward/record.url?scp=85124341380&partnerID=8YFLogxK
U2 - 10.1007/s00404-022-06410-w
DO - 10.1007/s00404-022-06410-w
M3 - Article
C2 - 35133455
SN - 0932-0067
VL - 306
SP - 1485
EP - 1494
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
IS - 5
ER -