Increased Incidence of Childhood Lymphoma in Children with a History of Small for Gestational Age at Birth

Roy Kessous, Eyal Sheiner, Guy Beck Rosen, Joseph Kapelushnik, Tamar Wainstock

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


OBJECTIVE: The aim of this study was to evaluate whether children that were born small for gestational age (SGA) have an increased risk for childhood neoplasm.

STUDY DESIGN: A population-based cohort analysis comparing the risk for long-term childhood neoplasms (benign and malignant) in children that were born SGA vs. those that were appropriate for gestational age (AGA), between the years1991-2014. Childhood neoplasms were predefined based on ICD-9 codes, as recorded in the hospital medical files. Kaplan-Meier survival curves were constructed to compare cumulative oncological morbidity in both groups over time. Cox proportional hazards model was used to control for confounders.

RESULTS: During the study period 231,973 infants met the inclusion criteria; out of those 10,998 were born with a diagnosis of SGA. Children that were SGA at birth had higher incidence of lymphoma (OR 2.50, 95% CI 1.06-5.82; p value = 0.036). In addition, cumulative incidence over time of total childhood lymphoma was significantly higher in SGA children (Log Rank = 0.030). In a Cox regression model controlling for other perinatal confounders; SGA at birth remained independently associated with an increased risk for childhood lymphoma (adjusted HR 2.41, 95% CI 1.03-5.56, p value = 0.043).

CONCLUSION: Being delivered SGA is associated with an increased long-term risk for childhood malignancy and specifically lymphoma.

Original languageEnglish
Pages (from-to)1485-1494
Number of pages10
JournalArchives of Gynecology and Obstetrics
Issue number5
Early online date8 Feb 2022
StateE-pub ahead of print - 8 Feb 2022


  • Childhood malignancy
  • Lymphoma
  • Small for gestational age

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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