TY - JOUR
T1 - Increased incidence with improved survival of gynecologic carcinosarcoma
T2 - A population-based study
AU - Salman, Lina
AU - Brudner, Yana
AU - Silverman, Barbara G.
AU - Hallak, Mordechai
AU - Bruchim, Ilan
N1 - Funding Information:
The authors would like to thank The Gertner Institute for Epidemiology and Health Policy Research and especially Bernice Oberman for assistance with the statistical analysis. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Objective: To evaluate trends in the incidence and survival of gynecologic carcinosarcoma over the last 35 years and to explore ethnic disparities. Study design: Using the Israeli National Cancer Registry database, all cases of gynecologic carcinosarcoma were included (1980–2014). Age at diagnosis, patient's ethnicity and anatomical site were extracted. Age-standardized incidence rates (ASRs) were calculated for 3 time periods (1980–1994, 1995–2004 and 2005–2014). Relative survival was calculated using the Pohar-Perme method. Results: Overall, 935 cases of gynecologic carcinosarcomas were diagnosed during 1980–2014. The most common gynecologic anatomical site was the uterus (83.4%). Most cases (66%) were diagnosed at ages 60–80, with median age of 69 years. There was a steady increase in ASRs from 5.6 to 8.2 per million women. Throughout 1980–1994 and 2005–2014, ASRs were significantly higher in the Jewish compared to the Arab population (5.8 vs. 3.1, p = 0.02 and 8.5 vs. 5.2, p = 0.002, respectively). Relative survival rates increased throughout the study period. No significant differences were noted in relative survival between the Jewish and Arab populations (p = 0.18). Conclusion: The incidence of gynecologic carcinosarcoma increased significantly from 1980 through 2014. Nevertheless, survival rates increased during this time, with no difference in survival between the Jewish and Arab populations.
AB - Objective: To evaluate trends in the incidence and survival of gynecologic carcinosarcoma over the last 35 years and to explore ethnic disparities. Study design: Using the Israeli National Cancer Registry database, all cases of gynecologic carcinosarcoma were included (1980–2014). Age at diagnosis, patient's ethnicity and anatomical site were extracted. Age-standardized incidence rates (ASRs) were calculated for 3 time periods (1980–1994, 1995–2004 and 2005–2014). Relative survival was calculated using the Pohar-Perme method. Results: Overall, 935 cases of gynecologic carcinosarcomas were diagnosed during 1980–2014. The most common gynecologic anatomical site was the uterus (83.4%). Most cases (66%) were diagnosed at ages 60–80, with median age of 69 years. There was a steady increase in ASRs from 5.6 to 8.2 per million women. Throughout 1980–1994 and 2005–2014, ASRs were significantly higher in the Jewish compared to the Arab population (5.8 vs. 3.1, p = 0.02 and 8.5 vs. 5.2, p = 0.002, respectively). Relative survival rates increased throughout the study period. No significant differences were noted in relative survival between the Jewish and Arab populations (p = 0.18). Conclusion: The incidence of gynecologic carcinosarcoma increased significantly from 1980 through 2014. Nevertheless, survival rates increased during this time, with no difference in survival between the Jewish and Arab populations.
KW - Carcinosarcoma
KW - Gynecologic
KW - Incidence
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=85116440505&partnerID=8YFLogxK
U2 - 10.1016/j.ejogrb.2021.09.025
DO - 10.1016/j.ejogrb.2021.09.025
M3 - Article
C2 - 34624737
AN - SCOPUS:85116440505
SN - 0028-2243
VL - 266
SP - 106
EP - 110
JO - European Journal of Obstetrics, Gynecology and Reproductive Biology
JF - European Journal of Obstetrics, Gynecology and Reproductive Biology
ER -
