Increased incidence with improved survival of gynecologic carcinosarcoma: A population-based study

Lina Salman, Yana Brudner, Barbara G. Silverman, Mordechai Hallak, Ilan Bruchim

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: To evaluate trends in the incidence and survival of gynecologic carcinosarcoma over the last 35 years and to explore ethnic disparities. Study design: Using the Israeli National Cancer Registry database, all cases of gynecologic carcinosarcoma were included (1980–2014). Age at diagnosis, patient's ethnicity and anatomical site were extracted. Age-standardized incidence rates (ASRs) were calculated for 3 time periods (1980–1994, 1995–2004 and 2005–2014). Relative survival was calculated using the Pohar-Perme method. Results: Overall, 935 cases of gynecologic carcinosarcomas were diagnosed during 1980–2014. The most common gynecologic anatomical site was the uterus (83.4%). Most cases (66%) were diagnosed at ages 60–80, with median age of 69 years. There was a steady increase in ASRs from 5.6 to 8.2 per million women. Throughout 1980–1994 and 2005–2014, ASRs were significantly higher in the Jewish compared to the Arab population (5.8 vs. 3.1, p = 0.02 and 8.5 vs. 5.2, p = 0.002, respectively). Relative survival rates increased throughout the study period. No significant differences were noted in relative survival between the Jewish and Arab populations (p = 0.18). Conclusion: The incidence of gynecologic carcinosarcoma increased significantly from 1980 through 2014. Nevertheless, survival rates increased during this time, with no difference in survival between the Jewish and Arab populations.

Original languageEnglish
Pages (from-to)106-110
Number of pages5
JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
StatePublished - 1 Nov 2021
Externally publishedYes


  • Carcinosarcoma
  • Gynecologic
  • Incidence
  • Survival

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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