Increased LAK activity against HIV-infected cell lines in HIV-1+ individuals

C. Gryllis, M. A. Wainberg, Z. Bentwich, M. Gornitsky, B. G. Brenner

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The role of natural killer (NK) cells and their inducible counterparts, lymphokine-activated killer (LAK) cells in AIDS with regard to HIV-1 viral immunosurveillance and the control of secondary opportunistic disease has yet to be established. In this study, we have demonstrated that LAK cells derived from all HIV-1+ groups showed striking increases in their capacity to lyse HIV-1-infected U-937 cells relative to their uninfected U-937 counterparts. Surprisingly, similarly derived LAK cells from healthy seronegative controls showed no differences in their lysis of HIV-1-infected versus uninfected U-937 cells. The differential ability of LAK effectors from seropositive donors to lyse HIV-1-infected targets was demonstrable using a number of U-937 subclones and their HIV-1-infected counterparts. Again, no differences in LAK cell-mediated lysis of HIV-1-infected and uninfected U-937 subclones were observed in seronegative individuals. Our findings that HIV-1+ individuals show selective expansion of non-MHC restricted, HIV-1-directed cytotoxic LAK cells indicate that natural immunity may indeed play a role in HIV-1 viral immunosurveillance.

Original languageEnglish
Pages (from-to)356-361
Number of pages6
JournalClinical and Experimental Immunology
Volume89
Issue number3
DOIs
StatePublished - 1 Jan 1992
Externally publishedYes

Keywords

  • AIDS
  • HIV
  • U-937
  • lymphokine-activated killer cells
  • natural killer cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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