Increased platelet thromboxane A2/prostaglandin H2 receptors in patients with pregnancy induced hypertension

N. Liel, I. Nathan, T. Yermiyahu, Z. Zolotov, J. R. Lieberman, A. Dvilansky, P. V. Halushka

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Pregnancy induced hypertension (PIH) is associated with a variety of disturbances in the hemostatic system including alterations in platelet function, thrombocytopenia (1), and an increase in platelet turnover (2,3). The density of platelet Thromboxane A2 (TXA2)/Prostaglandin H2 (PGH2) receptors was determined in patients with PIH and normal pregnant women, using [125I]-PTA-OH, a TXA2/PGH2 receptor antagonist. The number of platelet TXA2/PGH2 receptors significantly increased (p<0.008) from 1734±370 sites/platelet (n=8) in normal pregnant women to 3703±846 sites/platelet (n=9) in patients with severe PIH. The sensitivity of platelets to the TXA2 mimetic U46619 was significantly (p<0.0005) increased in platelets obtained from severe PIH patients (EC50=150±10nM, n=3) compared to controls (EC50=290±60nM, n=5). These results indicate that an increased number of TXA2/PGH2 receptors as well as increased sensitivity to TXA2/PGH2 mimetics occurs in PIH. Collectively, these results provide further support for the notion that TXA2 and its receptor may play an important role in the pathophysiology of PIH.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalThrombosis Research
Volume70
Issue number3
DOIs
StatePublished - 1 May 1993
Externally publishedYes

Keywords

  • Pregnancy induced hypertension
  • Thromboxane A/Prostaglandin H receptors
  • aggregation
  • platelets

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