Increased prevalence of attention-deficit hyperactivity disorder symptomatology in patients with familial Mediterranean fever

Eran Lavi, Aus Maree, Eli M. Eisenstein, Isaiah Wexler, Itai Berger, Yackov Berkun

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations

    Abstract

    Objectives: Previous studies suggest that exposure to inflammation in infancy may increase the risk for attention-deficit and hyperactivity disorder (ADHD). We studied the ADHD manifestations among 124 familial Mediterranean fever (FMF) patients and examined the relationship between FMF patient characteristics and ADHD. Methods: Clinical, demographic, and genetic data were abstracted from patients' medical records and supplemented by information obtained during clinic visits. ADHD manifestations were assessed using the Diagnostic and Statistical Manual of Mental Disorders (5th ed.) questionnaire. Results: ADHD was diagnosed in 42 (32.8%) FMF patients, a rate significantly higher than in unselected populations (∼8%). A majority (n = 27, 64.3%) had combined inattentive, hyperactive-impulsive manifestations. Eight (19%) had predominantly hyperactive-impulsive, and seven (16.6%) had predominantly inattentive symptoms. FMF patients with severe manifestations reported more ADHD symptoms. FMF patients with ADHD symptoms were less adherent to their treatment regimen, with only 61.9% of the patients with ADHD symptoms adhering to colchicine therapy compared to 92.7% of the patients without ADHD symptoms. Conclusion: The high prevalence of ADHD characteristics in children with FMF may support the neuroimmune hypothesis that chronic inflammation increases the risk for ADHD. Children with FMF should be screened for ADHD as its presence may adversely affect adherence to treatment.

    Original languageEnglish
    Pages (from-to)422-426
    Number of pages5
    JournalModern Rheumatology
    Volume32
    Issue number2
    DOIs
    StatePublished - 1 Mar 2022

    Keywords

    • ADHD
    • FMF
    • autoinflammatory
    • child compliance

    ASJC Scopus subject areas

    • Medicine (all)

    Fingerprint

    Dive into the research topics of 'Increased prevalence of attention-deficit hyperactivity disorder symptomatology in patients with familial Mediterranean fever'. Together they form a unique fingerprint.

    Cite this