Increased protein synthesis by human platelets during phagocytosis of latex particles in vitro

H. Bessler, G. Agam, M. Djaldetti

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A three fold increase of protein synthesis by human platelets during in vitro phagocytosis of polystyrene latex particles was detected. During the first two hours of incubation, the percentage of phagocytizing platelets and the number of latex particles per platelet increased; by the end of the third hour, the first parameter remained stable, while the number of latex particles per cell had decreased. Vincristine (20 μg/ml of cell suspension) inhibited platelet protein synthesis. This effect was both time and dose dependent. The drug also caused a decrease in the number of phagocytizing cells, as well as in their phagocytotic activity.

Original languageEnglish
Pages (from-to)350-357
Number of pages8
JournalTHROMB.DIATHES.HAEMORRH.
Volume35
Issue number2
DOIs
StatePublished - 1 Jan 1976
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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