Indole-3-carbinol: A plant hormone combatting cancer [version 1; referees: 2 approved]

Daniel A. Chamovitz, Ella Katz, Sophia Nisani

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

A diet rich in cruciferous vegetables such as cauliflower, broccoli, and cabbage has long been considered healthy, and various epidemiological studies suggest that the consumption of cruciferous vegetables contributes to a cancer-protecting diet. While these vegetables contain a vast array of phytochemicals, the mechanism by which these vegetables counteract cancer is still largely unresolved. Numerous in situ studies have implicated indole-3-carbinol, a breakdown product of the glucosinolate indole-3-ylmethylglucosinolate, as one of the phytochemicals with anti-cancer properties. Indole-3-carbinol influences a range of cellular processes, but the mechanisms by which it acts on cancer cells are slowly being revealed. Recent studies on the role of indole-3-carbinol in Arabidopsis opens the door for cross-kingdom comparisons that can help in understanding the roles of this important phytohormone in both plant biology and combatting cancer.

Original languageEnglish
Article number689
JournalF1000Research
Volume7
DOIs
StatePublished - 1 Jan 2018
Externally publishedYes

Keywords

  • Cancer prevention
  • Cruciferous vegetables
  • Glucosinolates
  • Indole-3-carbinol

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)
  • Immunology and Microbiology (all)
  • Pharmacology, Toxicology and Pharmaceutics (all)

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