Induction and treatment of the antiphospholipid syndrome - Lessons from animal models

Y. Shoenfeld, M. Blank, Y. Sherer

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


The diagnosis of antiphospholipid syndrome (APS) is based on a combination of clinical and serological criteria. This review summarizes the literature regarding animal models of APS. Animal models of this syndrome help to elucidate pathogenic roles of the characteristic antiphospholipid antibodies in pregnancy morbidity, vascular thrombosis, neurologic disease and atherosclerosis. Furthermore, these models also provide measures to evaluate novel therapies for APS. These include bone-marrow transplantation, intravenous immunoglobulin, anticoagulation, interleukin-3, in addition to other therapies. Experimental induction and treatment of APS largely contributes to our understanding of the disease and to better management of its clinical characteristics.

Original languageEnglish
Pages (from-to)736-740
Number of pages5
JournalEuropean Journal of Clinical Investigation
Issue number8
StatePublished - 29 Aug 2001
Externally publishedYes


  • Animal model
  • Anticardiolipin
  • Antiphospholipid syndrome


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