Induction of diffuse axonal brain injury in rats based on rotational acceleration

Dmitry Frank, Israel Melamed, Benjamin F. Gruenbaum, Julia Grinshpun, Ruslan Kuts, Rachel Shvartsur, Abed N. Azab, Mohamad H. Assadi, Max Vinokur, Matthew Boyko

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Traumatic brain injury (TBI) is a major cause of death and disability. Diffuse axonal injury (DAI) is the predominant mechanism of injury in a large percentage of TBI patients requiring hospitalization. DAI involves widespread axonal damage from shaking, rotation or blast injury, leading to rapid axonal stretch injury and secondary axonal changes that are associated with a long-lasting impact on functional recovery. Historically, experimental models of DAI without focal injury have been difficult to design. Here we validate a simple, reproducible and reliable rodent model of DAI that causes widespread white matter damage without skull fractures or contusions.

Original languageEnglish
Article numbere61198
JournalJournal of Visualized Experiments
Volume2020
Issue number159
DOIs
StatePublished - 1 May 2020

Keywords

  • Diffuse axonal injury (DAI)
  • Issue 159
  • Neuroscience
  • Rat model
  • Rotational acceleration
  • Stretch injury
  • Traumatic brain injury (TBI)
  • White matter

ASJC Scopus subject areas

  • Neuroscience (all)
  • Chemical Engineering (all)
  • Biochemistry, Genetics and Molecular Biology (all)
  • Immunology and Microbiology (all)

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