Infection and the etiology and pathogenesis of multiple sclerosis

Israel Steiner, Puiu Nisipianu, Itzhak Wirguin

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Multiple sclerosis (MS) currently defies clinical and scientific definitions, and carries a prognosis that remains practically unchanged despite many years of intensive research. Although the prevailing dogma is that MS is an immune-mediated condition, it fulfills none of the criteria of an autoimmune disease. On the other hand, there is enough significant data to suggest that infectious agents(s) could be involved in either direct damage to the white matter or induce inflammatory responses that secondarily affect the brain. Our goal here is to review the data supporting the possibility that infection has a critical role in the disease, examine the list of potential candidates that have been suggested, and outline an approach regarding the potential role of infectious agents in the etiology and pathogenesis of MS.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalCurrent Neurology and Neuroscience Reports
Issue number3
StatePublished - 1 May 2001
Externally publishedYes


  • Demyelinating Disorder
  • Herpes Simplex Virus Type
  • Multiple Sclerosis
  • Progressive Multifocal Leukoencephalopathy
  • Representational Difference Analysis

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


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