Infection by different HIV-1 subtypes (B and C) results in a similar immune activation profile despite distinct immune backgrounds

Ziva Weisman, Alexander Kalinkovich, Gadi Borkow, Michael Stein, Zalman Greenberg, Zvi Bentwich

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


We compared the immune activation profile of 46 HIV-negative and 75 HIV- positive Israelis infected with HIV-1 subtype B, with 85 HIV-negative and 102 HIV-positive Ethiopian immigrants to Israel, who were infected with HIV subtype C. The HIV-negative Ethiopians had exceedingly high blood levels of eosinophils, immunoglobulin E (IgE), and p75s tumor-necrosis factor receptors (p75sTNFR); secretion of interleukin-4 (IL-4) and IL-10 by peripheral blood mononuclear cells (PBMC); proportion of human leukocyte antigen (HLA)-DR+ cells within CD3+, CD4+, and CD8+ T-cell subsets; and proportion of CD45RO+ CD4+ cells; while having significantly lower secretion of interferon-γ (IFN-γ) by PBMC and percentage of CD45RA+ CD4+ and CD28+ CD8+ cells. HIV infection in both populations was associated with reduced IL-2, IL-4, IL-10, and IL-12 secretion, number of CD28+ and CD45RA+ CD8+ cells, and increased number of HLA-DR+-CD3+, CD4+, and CD8+ cells, and CD45RO+ CD8+ cells. Thus, infection with HIV-1 subtypes B and C of studied Israelis and Ethiopians, respectively, results in a similar immune activation profile at all stages of the infection when living in the same environment, despite the striking different immune profile observed in the HIV-negative Israeli and Ethiopian populations. Together with our previous observations, this indicates that HIV subtype is not a major determinant in the natural course of HIV infection.

Original languageEnglish
Pages (from-to)157-163
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Issue number2
StatePublished - 1 Jun 1999
Externally publishedYes


  • Cytokine secretion
  • Ethiopian immigrants
  • HIV-1 subtypes
  • HIV-infection
  • Immune activation
  • T-cell surface markers

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology


Dive into the research topics of 'Infection by different HIV-1 subtypes (B and C) results in a similar immune activation profile despite distinct immune backgrounds'. Together they form a unique fingerprint.

Cite this