TY - JOUR
T1 - Infection with Simkania negevensis in Brooklyn, New York
AU - Kumar, Swati
AU - Kohlhoff, Stephan A.
AU - Gelling, Maureen
AU - Roblin, Patricia M.
AU - Kutlin, Andrei
AU - Kahane, Simona
AU - Friedman, Maureen G.
AU - Hammerschlag, Margaret R.
N1 - Funding Information:
Supported by grant 95-119 from the United States-Israel Binational Science Foundation (Jerusalem, Israel).
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Background: Simkania negevensis is a Chlamydia-like intracellular organism that is prevalent in populations from a wide range of geographic areas. The role of the organism in respiratory disease in the United States is unknown. Objective: To study the association between infection with S. negevensis and bronchiolitis, pneumonia or asthma in Brooklyn, New York. Materials and Methods: Pediatric and adult inpatients/outpatients with bronchiolitis, pneumonia or asthma were recruited, and a similar number of healthy control subjects were enrolled. Nasopharyngeal swabs were obtained for culture of S. negevensis and Chlamydia pneumoniae and polymerase chain reaction detection of S. negevensis. Sera were obtained for measurement of antibodies to S. negevensis and C. pneumoniae. Results: One hundred eighty-eight patients and 110 healthy control subjects were enrolled. S. negevensis serologic assays were positive for 18% of patients, compared with 29% of control subjects (P = 0.09). S. negevensis DNA was detected by PCR for 17% of case subjects and 23% of control subjects (P = 0.25). S. negevensis was isolated by culture for 1 patient with bronchiolitis. C. pneumoniae IgG and S. negevensis IgG were found to increase with increasing age, ie, 14%, 50% and 78% (C. pneumoniae) and 13%, 17% and 33% (S. negevensis) for subjects 0-18 months, 18 months-18 years and older than 18 years of age, respectively. Conclusion: S. negevensis was not a significant respiratory pathogen in Brooklyn, NY, during the period of the study.
AB - Background: Simkania negevensis is a Chlamydia-like intracellular organism that is prevalent in populations from a wide range of geographic areas. The role of the organism in respiratory disease in the United States is unknown. Objective: To study the association between infection with S. negevensis and bronchiolitis, pneumonia or asthma in Brooklyn, New York. Materials and Methods: Pediatric and adult inpatients/outpatients with bronchiolitis, pneumonia or asthma were recruited, and a similar number of healthy control subjects were enrolled. Nasopharyngeal swabs were obtained for culture of S. negevensis and Chlamydia pneumoniae and polymerase chain reaction detection of S. negevensis. Sera were obtained for measurement of antibodies to S. negevensis and C. pneumoniae. Results: One hundred eighty-eight patients and 110 healthy control subjects were enrolled. S. negevensis serologic assays were positive for 18% of patients, compared with 29% of control subjects (P = 0.09). S. negevensis DNA was detected by PCR for 17% of case subjects and 23% of control subjects (P = 0.25). S. negevensis was isolated by culture for 1 patient with bronchiolitis. C. pneumoniae IgG and S. negevensis IgG were found to increase with increasing age, ie, 14%, 50% and 78% (C. pneumoniae) and 13%, 17% and 33% (S. negevensis) for subjects 0-18 months, 18 months-18 years and older than 18 years of age, respectively. Conclusion: S. negevensis was not a significant respiratory pathogen in Brooklyn, NY, during the period of the study.
KW - Asthma
KW - Bronchiolitis
KW - Chlamydia pneumoniae
KW - Pneumonia
KW - Simkania negevensis
UR - http://www.scopus.com/inward/record.url?scp=28044434163&partnerID=8YFLogxK
U2 - 10.1097/01.inf.0000183755.24578.0b
DO - 10.1097/01.inf.0000183755.24578.0b
M3 - Article
AN - SCOPUS:28044434163
SN - 0891-3668
VL - 24
SP - 989
EP - 992
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - 11
ER -