Inflammation und Blut-Hirn-Schranke

The neuropil of the central nervous system is separated from the vasculature by the blood–brain barrier, with the exception of the circumventricular organs. It prevents toxic substances, pathogens, antibodies and peripheral immune cells from entering the brain parenchyma. Autoimmune disorders targeting the central nervous system require a disturbance in this barrier function. In fact, various neurological disorders are accompanied if not in part caused by blood-brain barrier dysfunction. Novel imaging methods can detect altered blood–brain barrier permeability, whose duration and extent is of prognostic value.