Inflammatory bowel disease and preterm delivery

G. Elbaz, A. Fich, A. Levy, G. Holcberg, E. Sheiner

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Objective: The present study investigates pregnancy outcome in women with IBD and examines the effect of pregnancy on the severity of IBD. Method: A case-control study comparing deliveries by mothers with IBD between January 1988 and January 2005 was performed. For every birth by a mother with IBD, four births by non-IBD mothers were randomly selected and adjusted for ethnicity and year of delivery. Result: During the study period there were 48 deliveries to patients with Crohn's disease and 79 deliveries to patients with ulcerative colitis. Higher rates of preterm delivery (< 37 weeks) were found among patients with IBD as compared to the controls (odds ratios (OR) = 2.2; 95% confidence interval (CI) = 1.3-3.8). This association remained significant after adjustment for labor induction and multiple gestations, using the Mantel-Haenszel technique (weighted OR = 2.1; 95% CI 1.3-3.5 and weighted OR = 2.0; 95% CI 1.2-3.5; P = 0.012; respectively). In addition, these patients had higher rates of fertility treatments (OR = 2.2; 95% CI = 1.1-4.4). Using a multivariate analysis, controlling for maternal age and fertility treatments, preterm delivery was seen to be significantly associated with IBD (adjusted OR = 2.0; 95% CI = 1.2-3.5). Perinatal outcomes, such as perinatal mortality, low Apgar scores, and congenital malformations, were comparable to the outcomes in the control group. Conclusion: Maternal IBD is an independent risk factor for preterm delivery. IBD is not associated with adverse perinatal outcome.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalInternational Journal of Gynecology and Obstetrics
Issue number3
StatePublished - 1 Jan 2005


  • Crohn's disease
  • Fertility
  • Inflammatory bowel disease
  • Pregnancy outcome
  • Preterm delivery
  • Ulcerative colitis

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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