Inflammatory injury to the neonatal brain - what can we do?

Noa Ofek-Shlomai, Itai Berger

Research output: Contribution to journalShort surveypeer-review

15 Scopus citations

Abstract

Perinatal brain damage is one of the leading causes of life long disability. This damage could be hypoxic-ischemic, inflammatory, or both. This mini-review discusses different interventions aiming at minimizing inflammatory processes in the neonatal brain, both before and after insult. Current options of anti-inflammatory measures for neonates remain quite limited. We describe current anti-inflammatory intervention strategies such as avoiding perinatal infection and inflammation, and reducing exposure to inflammatory processes. We describe the known effects of anti-inflammatory drugs such as steroids, antibiotics, and indomethacin, and the possible anti-inflammatory role of other substances such as IL-1 receptor antagonists, erythropoietin, caffeine, estradiol, insulin-like growth factor, and melatonin as well as endogenous protectors, and genetic regulation of inflammation. If successful, these may decrease mortality and long-term morbidity among term and pre-term infants.

Original languageEnglish
Article number30
JournalFrontiers in Pediatrics
Volume2
Issue numberAPR
DOIs
StatePublished - 1 Apr 2014
Externally publishedYes

Keywords

  • Brain injury
  • Inflammation
  • Neonatal
  • Neuro-developmental outcome
  • Treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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