TY - JOUR
T1 - Inflammatory reaction in acute retinal artery occlusion
T2 - Cytokine levels in aqueous humor and serum
AU - Kramer, Michal
AU - Goldenberg-Cohen, Nitza
AU - Axer-Siegel, Ruth
AU - Weinberger, Dov
AU - Cohen, Yoram
AU - Monselise, Yehudit
N1 - Funding Information:
Accepted 9 October 2004. Supported by the Gothalf Fund, Tel Aviv University, Israel. Correspondence and reprint requests to: M. Kramer, M.D., Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49 100, Israel. Tel: 972-3-937-6101; Fax: 972-3-921-9084; e-mail: [email protected]
PY - 2005/8/1
Y1 - 2005/8/1
N2 - Purpose: To investigate the role of inflammation in acute retinal artery occlusion (RAO). Methods: Levels of interleukin (IL)-6, IL-8, and tumor necrosis factor alpha (TNF-α) were measured in serum (n = 14) and aqueous humor (AqH) (n = 8) samples from patients with RAO. Findings were compared with 24 age- and disease-matched patients, 10 healthy subjects (serum), and 16 patients undergoing cataract surgery (AqH). Results: Patients who arrived early (within 4-6 hours of occlusion) had higher serum IL-8 and IL-6 levels than controls; the IL-6 level in the AqH was lower than that of controls, while the IL-8 level was higher. In seven patients for whom both serum and AqH samples were available, serum IL-6 levels were higher than their corresponding AqH levels in most patients arriving within 10 hours of occlusion, and AqH IL-8 levels were higher than the corresponding serum levels in all but one. TNF-α levels were consistently higher in the serum than in the AqH at all time points. Conclusions: Serum IL-8 and IL-6 and AqH IL-8 are elevated immediately following acute RAO. The early local suppression of IL-6 may be related to ocular immune mechanisms.
AB - Purpose: To investigate the role of inflammation in acute retinal artery occlusion (RAO). Methods: Levels of interleukin (IL)-6, IL-8, and tumor necrosis factor alpha (TNF-α) were measured in serum (n = 14) and aqueous humor (AqH) (n = 8) samples from patients with RAO. Findings were compared with 24 age- and disease-matched patients, 10 healthy subjects (serum), and 16 patients undergoing cataract surgery (AqH). Results: Patients who arrived early (within 4-6 hours of occlusion) had higher serum IL-8 and IL-6 levels than controls; the IL-6 level in the AqH was lower than that of controls, while the IL-8 level was higher. In seven patients for whom both serum and AqH samples were available, serum IL-6 levels were higher than their corresponding AqH levels in most patients arriving within 10 hours of occlusion, and AqH IL-8 levels were higher than the corresponding serum levels in all but one. TNF-α levels were consistently higher in the serum than in the AqH at all time points. Conclusions: Serum IL-8 and IL-6 and AqH IL-8 are elevated immediately following acute RAO. The early local suppression of IL-6 may be related to ocular immune mechanisms.
KW - Cytokines
KW - IL-6
KW - IL-8
KW - Retinal artery occlusion
KW - TNF-α
UR - http://www.scopus.com/inward/record.url?scp=26944486696&partnerID=8YFLogxK
U2 - 10.1080/09273940590950990
DO - 10.1080/09273940590950990
M3 - Article
C2 - 16159722
AN - SCOPUS:26944486696
SN - 0927-3948
VL - 13
SP - 305
EP - 310
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 4
ER -
