Influence of H-2K transfection on susceptibility of fibrosarcoma tumor cells to natural killer (NK) cells

Jacob Gopas, Shraga Segal, Gunter Hammerling, Menashe Bar-Eli, Bracha Rager-Zisman

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

In this study, we have used the T-10 fibrosarcoma tumor cells to further analyze the relationship between metastatic competence, expression of H-2K antigens and susceptibility to lysis by virus augmented NK cells in vitro. Our results show an inverse correlation between metastatic properties of the original T-10 clones, IC9 and IE7, and susceptibility in vitro to lysis by virus-augmented NK cells. Restoration by transfection of expression of H-2K genes (H-2Kb or H-2Kk) led to the alteration of the metastatic phenotype of the tumors cells, yet had minor influence on the putative susceptibility of these clones to NK. These observations suggest that expression of MHC gene products, while affecting metastases, does not exclusively determine sensitivity to NK cells.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalImmunology Letters
Volume17
Issue number3
DOIs
StatePublished - 1 Jan 1988

Keywords

  • H-2K transfection
  • Metastasis
  • Natural killer cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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