Influence of sarcopenia, clinical data, and 2-[18F] FDG PET/CT in outcome prediction of patients with early-stage adenocarcinoma esophageal cancer

Reut Anconina; Claudia Ortega; Ur Metser; Zhihui Amy Liu; Chihiro Suzuki; Micheal McInnis; Gail E. Darling; Rebecca Wong; Kirsty Taylor; Jonathan Yeung; Eric X. Chen; Carol J. Swallow; Jaspreet Bajwa; Raymond W. Jang; Elena Elimova; Patrick Veit-Haibach

doi:10.1007/s00259-021-05514-w

Influence of sarcopenia, clinical data, and 2-[¹⁸F] FDG PET/CT in outcome prediction of patients with early-stage adenocarcinoma esophageal cancer

Reut Anconina, Claudia Ortega, Ur Metser, Zhihui Amy Liu, Chihiro Suzuki, Micheal McInnis, Gail E. Darling, Rebecca Wong, Kirsty Taylor, Jonathan Yeung, Eric X. Chen, Carol J. Swallow, Jaspreet Bajwa, Raymond W. Jang, Elena Elimova, Patrick Veit-Haibach

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Purpose: To determine the prognostic value of sarcopenia measurements done on staging 2-[18F] FDG PET/CT together with metabolic activity of the tumor in patients with adenocarcinoma esophagogastric cancer with surgical treatment. Methods: Patients with early-stage, surgically treated esophageal adenocarcinoma and available pre-treatment 2-[18F] FDG PET/CT were included. The standard uptake value (SUV) and SUV normalized by lean body mass (SUL) were recorded. Skeletal muscle index (SMI) was measured at the L3 level on the CT component of the PET/CT. Sarcopenia was defined as SMI < 34.4cm²/m² in women and < 45.4cm²/m² in men. Results: Of the included 145 patients. 30% were sarcopenic at baseline. On the univariable Cox proportional hazards analysis, ECOG, surgical T and N staging, lymphovascular invasion (LVI) positive lymph nodes, and sarcopenia were significant prognostic factors concerning RFS and OS. On multivariable Cox regression analysis, surgical N staging (p = 0.025) and sarcopenia (p = 0.022) remained significant poor prognostic factors for OS and RFS. Combining the clinical parameters with the imaging-derived nutritional evaluation of the patient but not metabolic parameters of the tumor showed improved predictive ability for OS and RFS. Conclusion: Combining the patients’ imaging-derived sarcopenic status with standard clinical data, but not metabolic parameters, offered an overall improved prognostic value concerning OS and RFS.

Original language	English
Pages (from-to)	1012-1020
Number of pages	9
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	49
Issue number	3
DOIs	https://doi.org/10.1007/s00259-021-05514-w
State	Published - 1 Feb 2022
Externally published	Yes

Keywords

Esophageal adenocarcinoma
Outcome prediction
PET/CT
Sarcopenia

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00259-021-05514-w

Cite this

Anconina, R., Ortega, C., Metser, U., Liu, Z. A., Suzuki, C., McInnis, M., Darling, G. E., Wong, R., Taylor, K., Yeung, J., Chen, E. X., Swallow, C. J., Bajwa, J., Jang, R. W., Elimova, E., & Veit-Haibach, P. (2022). Influence of sarcopenia, clinical data, and 2-[¹⁸F] FDG PET/CT in outcome prediction of patients with early-stage adenocarcinoma esophageal cancer. European Journal of Nuclear Medicine and Molecular Imaging, 49(3), 1012-1020. https://doi.org/10.1007/s00259-021-05514-w

@article{24cc16a85c954ad7abc64364f8f799a0,

title = "Influence of sarcopenia, clinical data, and 2-[18F] FDG PET/CT in outcome prediction of patients with early-stage adenocarcinoma esophageal cancer",

abstract = "Purpose: To determine the prognostic value of sarcopenia measurements done on staging 2-[18F] FDG PET/CT together with metabolic activity of the tumor in patients with adenocarcinoma esophagogastric cancer with surgical treatment. Methods: Patients with early-stage, surgically treated esophageal adenocarcinoma and available pre-treatment 2-[18F] FDG PET/CT were included. The standard uptake value (SUV) and SUV normalized by lean body mass (SUL) were recorded. Skeletal muscle index (SMI) was measured at the L3 level on the CT component of the PET/CT. Sarcopenia was defined as SMI < 34.4cm2/m2 in women and < 45.4cm2/m2 in men. Results: Of the included 145 patients. 30% were sarcopenic at baseline. On the univariable Cox proportional hazards analysis, ECOG, surgical T and N staging, lymphovascular invasion (LVI) positive lymph nodes, and sarcopenia were significant prognostic factors concerning RFS and OS. On multivariable Cox regression analysis, surgical N staging (p = 0.025) and sarcopenia (p = 0.022) remained significant poor prognostic factors for OS and RFS. Combining the clinical parameters with the imaging-derived nutritional evaluation of the patient but not metabolic parameters of the tumor showed improved predictive ability for OS and RFS. Conclusion: Combining the patients{\textquoteright} imaging-derived sarcopenic status with standard clinical data, but not metabolic parameters, offered an overall improved prognostic value concerning OS and RFS.",

keywords = "Esophageal adenocarcinoma, Outcome prediction, PET/CT, Sarcopenia",

author = "Reut Anconina and Claudia Ortega and Ur Metser and Liu, {Zhihui Amy} and Chihiro Suzuki and Micheal McInnis and Darling, {Gail E.} and Rebecca Wong and Kirsty Taylor and Jonathan Yeung and Chen, {Eric X.} and Swallow, {Carol J.} and Jaspreet Bajwa and Jang, {Raymond W.} and Elena Elimova and Patrick Veit-Haibach",

note = "Funding Information: PVH received IIS grants, speakers fees, and travel support from Siemens Healthineers within the last 36 months. All of those are unrelated to the here presented work. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2022",

month = feb,

day = "1",

doi = "10.1007/s00259-021-05514-w",

language = "English",

volume = "49",

pages = "1012--1020",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

publisher = "Springer Verlag",

number = "3",

}

Anconina, R, Ortega, C, Metser, U, Liu, ZA, Suzuki, C, McInnis, M, Darling, GE, Wong, R, Taylor, K, Yeung, J, Chen, EX, Swallow, CJ, Bajwa, J, Jang, RW, Elimova, E & Veit-Haibach, P 2022, 'Influence of sarcopenia, clinical data, and 2-[¹⁸F] FDG PET/CT in outcome prediction of patients with early-stage adenocarcinoma esophageal cancer', European Journal of Nuclear Medicine and Molecular Imaging, vol. 49, no. 3, pp. 1012-1020. https://doi.org/10.1007/s00259-021-05514-w

Influence of sarcopenia, clinical data, and 2-[¹⁸F] FDG PET/CT in outcome prediction of patients with early-stage adenocarcinoma esophageal cancer. / Anconina, Reut; Ortega, Claudia; Metser, Ur et al.
In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 49, No. 3, 01.02.2022, p. 1012-1020.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Influence of sarcopenia, clinical data, and 2-[18F] FDG PET/CT in outcome prediction of patients with early-stage adenocarcinoma esophageal cancer

AU - Anconina, Reut

AU - Ortega, Claudia

AU - Metser, Ur

AU - Liu, Zhihui Amy

AU - Suzuki, Chihiro

AU - McInnis, Micheal

AU - Darling, Gail E.

AU - Wong, Rebecca

AU - Taylor, Kirsty

AU - Yeung, Jonathan

AU - Chen, Eric X.

AU - Swallow, Carol J.

AU - Bajwa, Jaspreet

AU - Jang, Raymond W.

AU - Elimova, Elena

AU - Veit-Haibach, Patrick

N1 - Funding Information: PVH received IIS grants, speakers fees, and travel support from Siemens Healthineers within the last 36 months. All of those are unrelated to the here presented work. Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2022/2/1

Y1 - 2022/2/1

N2 - Purpose: To determine the prognostic value of sarcopenia measurements done on staging 2-[18F] FDG PET/CT together with metabolic activity of the tumor in patients with adenocarcinoma esophagogastric cancer with surgical treatment. Methods: Patients with early-stage, surgically treated esophageal adenocarcinoma and available pre-treatment 2-[18F] FDG PET/CT were included. The standard uptake value (SUV) and SUV normalized by lean body mass (SUL) were recorded. Skeletal muscle index (SMI) was measured at the L3 level on the CT component of the PET/CT. Sarcopenia was defined as SMI < 34.4cm2/m2 in women and < 45.4cm2/m2 in men. Results: Of the included 145 patients. 30% were sarcopenic at baseline. On the univariable Cox proportional hazards analysis, ECOG, surgical T and N staging, lymphovascular invasion (LVI) positive lymph nodes, and sarcopenia were significant prognostic factors concerning RFS and OS. On multivariable Cox regression analysis, surgical N staging (p = 0.025) and sarcopenia (p = 0.022) remained significant poor prognostic factors for OS and RFS. Combining the clinical parameters with the imaging-derived nutritional evaluation of the patient but not metabolic parameters of the tumor showed improved predictive ability for OS and RFS. Conclusion: Combining the patients’ imaging-derived sarcopenic status with standard clinical data, but not metabolic parameters, offered an overall improved prognostic value concerning OS and RFS.

AB - Purpose: To determine the prognostic value of sarcopenia measurements done on staging 2-[18F] FDG PET/CT together with metabolic activity of the tumor in patients with adenocarcinoma esophagogastric cancer with surgical treatment. Methods: Patients with early-stage, surgically treated esophageal adenocarcinoma and available pre-treatment 2-[18F] FDG PET/CT were included. The standard uptake value (SUV) and SUV normalized by lean body mass (SUL) were recorded. Skeletal muscle index (SMI) was measured at the L3 level on the CT component of the PET/CT. Sarcopenia was defined as SMI < 34.4cm2/m2 in women and < 45.4cm2/m2 in men. Results: Of the included 145 patients. 30% were sarcopenic at baseline. On the univariable Cox proportional hazards analysis, ECOG, surgical T and N staging, lymphovascular invasion (LVI) positive lymph nodes, and sarcopenia were significant prognostic factors concerning RFS and OS. On multivariable Cox regression analysis, surgical N staging (p = 0.025) and sarcopenia (p = 0.022) remained significant poor prognostic factors for OS and RFS. Combining the clinical parameters with the imaging-derived nutritional evaluation of the patient but not metabolic parameters of the tumor showed improved predictive ability for OS and RFS. Conclusion: Combining the patients’ imaging-derived sarcopenic status with standard clinical data, but not metabolic parameters, offered an overall improved prognostic value concerning OS and RFS.

KW - Esophageal adenocarcinoma

KW - Outcome prediction

KW - PET/CT

KW - Sarcopenia

UR - http://www.scopus.com/inward/record.url?scp=85114299898&partnerID=8YFLogxK

U2 - 10.1007/s00259-021-05514-w

DO - 10.1007/s00259-021-05514-w

M3 - Article

C2 - 34491404

AN - SCOPUS:85114299898

SN - 1619-7070

VL - 49

SP - 1012

EP - 1020

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 3

ER -