Influence of smoking on outcome of COH and IUI in subfertile couples

Jacob Farhi, Raoul Orvieto

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Aim: To evaluate the influence of smoking on the outcome of COH and IUI in subfertile couples. Patients and methods: We reviewed the medical files of all consecutive women, age ≤ 35 years, attending our infertility clinics over an eigth-year period. Data on patient age, smoking habits, and variable related to infertility-treatment were collected from the files. Results: A total of 2,318 cases were evaluated: 1,803 in nonsmoking patients (n = 679) and 515 in smokers (n = 206). The smokers used significantly more gonadotropin ampoules and gained a thinner endometrium on the day of hCG administration than the nonsmokers (p < 0.016 for both). There were no between-groups differences in patient age, duration of gonadotropin stimulation, number of follicle >14 mm in diameter, or E2 levels on the day of hCG administration. Conclusion: Smokers undergoing COH with IUI required a significantly higher gonadotropin dosage than nonsmokers in order to achieved a comparable pregnancy rate.

Original languageEnglish
Pages (from-to)421-424
Number of pages4
JournalJournal of Assisted Reproduction and Genetics
Issue number7
StatePublished - 1 Jul 2009


  • COH
  • IUI
  • Infertility
  • Pregnancy rate
  • Smoking

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)


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