Influence of stress and health-behaviour on miRNA expression

Yori Gidron, Martina De Zwaan, Karl Quint, Matthias Ocker

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Psychological stress is correlated with and may even cause DNA damage, which contributes to the etiology of various diseases. Recent studies point to the role of micro-RNA (miRNA), small molecules that regulate gene expression, in health and disease. This study investigated the relationship between transient stress and two cancer-related miRNAs, and determined whether health-behaviour moderated these relationships. Using a pre-post design, 37 German students completed measures on health-behaviour and perceived stress, the latter after a study break (low stress) and after an exam (high stress). On both occasions, students underwent blood tests to determine the expression of let-7b and miR-21, two miRNAs recently found to be related to cancer. The students reported significantly higher stress after the exam than in the study break period. The levels of let-7b and miR-21 expression significantly declined from low- to high-stress periods. Importantly, baseline health-behaviour interacted with time in relation to miR-21, such that the expression of this marker decreased only in students with inadequate health-behaviour, while it did not change in students with adequate health-behaviour. This is the first study showing that brief academic stress can alter the expression of two cancer-related miRNA molecules, and that health-behaviour may moderate these effects for miR-21.

Original languageEnglish
Pages (from-to)455-457
Number of pages3
JournalMolecular Medicine Reports
Volume3
Issue number3
DOIs
StatePublished - 1 Jan 2010
Externally publishedYes

Keywords

  • Health-behaviour
  • Micro-RNA
  • Psychological stress

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Oncology
  • Cancer Research

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