Infrared surface plasmon spectroscopy of living cells

M. Golosovsky, V. Yashunsky, A. Zilberstein, T. Marciano, V. Lirtsman, D. Davidov, B. Aroeti

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

We report a spectroscopic technique that combines the Fourier-Transform Infrared Spectroscopy with the Surface Plasmon Resonance. This tool enables sensitive infrared spectroscopy of liquid and solid objects in the attenuated total reflectance mode. The FTIR-SPR technique is similar to FTIR-ATR technique but has higher sensitivity due to resonance amplification of the surface electric field. The label-free FTIR-SPR technique is especially advantageous for living cell studies since it combines spectroscopic information inherent to FTIR with structural information provided by the Surface Plasmon Resonance. We discuss the FTIR-SPR technique for label-free studies of cell sedimentation and spreading on substrate and for surface plasmon spectroscopy.

Original languageEnglish
Title of host publicationPlasmons
Subtitle of host publicationTheory and Applications
PublisherNova Science Publishers, Inc.
Pages327-343
Number of pages17
ISBN (Print)9781617613067
StatePublished - 1 Feb 2011
Externally publishedYes

Keywords

  • Biosensor
  • Cell culture
  • FTIR
  • Infrared
  • Surface plasmon

ASJC Scopus subject areas

  • Physics and Astronomy (all)

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