Inhaled budesonide for chronic obstructive pulmonary disease

Paltiel Weiner, Doron Zamir, Marinella Beckerman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A significant, large mimority of patients with chronic obstructive pulmonary disease (COPD) respond favorably to corticosteroid treatment; but the benefit may be outweighed by its side effects. Long-term administration of inhaled steroids is a safe means of treatment. We hypothesized that treatment with inhaled budesonide would improve clinical symptoms and pulmonary function in subjects with COPD, and that the response to an inhaled B2-agonist would individualize steroid responders. In 44 patients with stable COPD in a double-blind crossover trial, we compared a 6-week course of inhalations of 800 μg/d budesonide with a placebo, separated by a 4-week interval when no medication was taken. In 33 out of 42 responders to the B2-agonist who remained in the study, there was a significant improvement in FEV1 of greater than 20% following budesonide inhalation, as compared to placebo. There was also a significant difference between the 2 periods of treatment as to the mean number of B2-agonist inhalations. We conclude that about 1/4 of patients with stable COPD respond to bronchodilators, and treatment with inhaled steroids improves spirometry data and inhaled B2-agonist consumption in about 3/4.

Original languageEnglish
Pages (from-to)756-759+823
JournalHarefuah
Volume132
Issue number11
StatePublished - 1 Jun 1997
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (all)

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