Inhibition by antibiotic tetracyclines of rat cortical noradrenergic adenylate cyclase and amphetamine-induced hyperactivity

O. Kofman, E. Klein, M. Newman, R. Hamburger, O. Kimchi, T. Nir, H. Shimon, R. H. Belmaker

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Two antibiotic tetracyclines, demeclocycline (DMC) and minocycline, share several biochemical and behavioral properties with lithium (Li). DMC inhibited both noradrenaline- and chloradenosine-sensitive cyclic AMP accumulation in rat cerebral cortical slices both in vitro and ex vivo following two weeks of chronic dietary treatment. Minocycline, a lipophilic tetracycline, produced similar results in vitro. Both DMC and minocycline reduced open-field activity levels in rats following acute treatment, four hours prior to testing. Moreover, both drugs inhibited amphetamine-induced hyperactivity in the open field. Chronic treatment with 0.4% and 0.8% dietary DMC for two weeks attenuated amphetamine hyperactivity without affecting baseline activity levels in the open field. Neither DMC nor minocycline attenuated apomorphine-induced stereotypy at doses that attenuated amphetamine hyperactivity, a profile which is similar to that of lithium. Unlike lithium, however, DMC did not reverse reserpine-induced hypoactivity.

Original languageEnglish
Pages (from-to)417-424
Number of pages8
JournalPharmacology Biochemistry and Behavior
Volume37
Issue number3
DOIs
StatePublished - 1 Jan 1990

Keywords

  • Adenylate cyclase
  • Amphetamine
  • Bipolar affective illness
  • Demeclocycline
  • Lithium
  • Minocycline

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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