Inhibition of amyloid fibril growth and dissolution of amyloid fibrils by curcumin-gold nanoparticles

Sharbari Palmal, Amit Ranjan Maity, Brijesh Kumar Singh, Sreetama Basu, Nihar R. Jana, Nikhil R. Jana

Research output: Contribution to journalArticlepeer-review

130 Scopus citations

Abstract

Inhibition of amyloid fibrillation and clearance of amyloid fibrils/plaques are essential for the prevention and treatment of various neurodegenerative disorders involving protein aggregation. Herein, we report curcumin- functionalized gold nanoparticles (Au-curcumin) of hydrodynamic diameter 10-25 nm, which serve to inhibit amyloid fibrillation and disintegrate/dissolve amyloid fibrils. In nanoparticle form, curcumin is water-soluble and can efficiently interact with amyloid protein/peptide, offering enhanced performance in inhibiting amyloid fibrillation and dissolving amyloid fibrils. Our results imply that nanoparticle-based artificial molecular chaperones may offer a promising therapeutic approach to combat neurodegenerative disease. Nanoparticles in amyloid therapy: Curcumin-functionalized water-soluble gold nanoparticles have been found to efficiently inhibit amyloid fibril growth and to disintegrate preformed amyloid fibrils (see figure). Consequently, they serve to reduce amyloid-induced neurotoxicity.

Original languageEnglish
Pages (from-to)6184-6191
Number of pages8
JournalChemistry - A European Journal
Volume20
Issue number20
DOIs
StatePublished - 12 May 2014
Externally publishedYes

Keywords

  • amyloid beta-peptides
  • amyloid fibrils
  • curcumin
  • fibril dissolution
  • gold nanoparticles
  • neurochemistry

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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