Inhibition of cancer growth and induction of apoptosis by BGP-13 and BGP-15, new calcipotriene-derived vitamin D3 analogs, in-vitro and in-vivo studies

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24 Scopus citations

Abstract

Summary: One of the most innovative approaches to the treatment of cancer entails the use of 1α,25-dihydroxyvitamin D3 (calcitriol) analogs to inhibit cancer cell growth. We demonstrate here that BGP-13, a new calcipotriene-based 1α,25-dihydroxyvitamin D3 analog that we synthesized in our laboratory, inhibits the growth of prostate cancer (LNCaP), breast cancer (MCF-7), and colon cancer (HT-29) cell lines. Moreover, we also show that BGP-13 causes cells both to accumulate in G0-G1 and to activate caspase-3 and undergo apoptosis. In addition, we observed elevated vitamin D receptor (VDR) mRNA and protein levels in both LNCaP and MCF-7 cells following the exposure of the two cell lines to BGP-13. Importantly, we found that both the new analog BGP-13 and also BGP-15, another calcipotriene-based analog we synthesized previously and about which we published recently, inhibit the growth of HT-29 tumor xenografts in nude mice.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalInvestigational New Drugs
Volume31
Issue number2
DOIs
StatePublished - 1 Jan 2013

Keywords

  • Apoptosis
  • Calcipotriene
  • Tumor xenografts
  • Vitamin D receptor
  • Vitamin D3

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)

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