Inhibition of ceramide metabolism key enzymes and its implication in cell physiology and pathology

Antonio Gómez-Muñoz; Alberto Ouro; Lide Arana; Io Guané Rivera; Marta Ordoñez; Patricia Gangoiti; Miguel Trueba

doi:10.2174/157340811799860551

Inhibition of ceramide metabolism key enzymes and its implication in cell physiology and pathology

Antonio Gómez-Muñoz, Alberto Ouro, Lide Arana, Io Guané Rivera, Marta Ordoñez, Patricia Gangoiti, Miguel Trueba

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The simple sphingolipids ceramide, sphingosine, ceramide 1-phosphate and sphingosine 1-phosphate, and their metabolizing enzymes are implicated in the regulation of vital cellular functions, including angiogenesis, celldifferentiation, migration, and cell growth and death. These sphingolipids are also involved in the establishment and progression of many illnesses including cardiovascular diseases such as atherosclerosis, or neurodegenerative diseases such as Parkinson's or Alzheimer's diseases, chronic inflammation, and cancer. Therefore, the development of inhibitors of the enzymes that are responsible for the synthesis and degradation of these metabolites may be essential tools for studying normal cell metabolism as well as for establishing new therapeutic strategies for treatment of disease.

Original language	English
Pages (from-to)	191-204
Number of pages	14
Journal	Current Enzyme Inhibition
Volume	7
Issue number	4
DOIs	https://doi.org/10.2174/157340811799860551
State	Published - 1 Dec 2011
Externally published	Yes

Keywords

Apoptosis
Cell migration
Cell proliferation
Ceramide-1-phosphate
Ceramides
Inflammation
Sphingolipids
Sphingosine 1-phosphate

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/157340811799860551

Cite this

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abstract = "The simple sphingolipids ceramide, sphingosine, ceramide 1-phosphate and sphingosine 1-phosphate, and their metabolizing enzymes are implicated in the regulation of vital cellular functions, including angiogenesis, celldifferentiation, migration, and cell growth and death. These sphingolipids are also involved in the establishment and progression of many illnesses including cardiovascular diseases such as atherosclerosis, or neurodegenerative diseases such as Parkinson's or Alzheimer's diseases, chronic inflammation, and cancer. Therefore, the development of inhibitors of the enzymes that are responsible for the synthesis and degradation of these metabolites may be essential tools for studying normal cell metabolism as well as for establishing new therapeutic strategies for treatment of disease.",

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AU - Gómez-Muñoz, Antonio

AU - Ouro, Alberto

AU - Arana, Lide

AU - Rivera, Io Guané

AU - Ordoñez, Marta

AU - Gangoiti, Patricia

AU - Trueba, Miguel

PY - 2011/12/1

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N2 - The simple sphingolipids ceramide, sphingosine, ceramide 1-phosphate and sphingosine 1-phosphate, and their metabolizing enzymes are implicated in the regulation of vital cellular functions, including angiogenesis, celldifferentiation, migration, and cell growth and death. These sphingolipids are also involved in the establishment and progression of many illnesses including cardiovascular diseases such as atherosclerosis, or neurodegenerative diseases such as Parkinson's or Alzheimer's diseases, chronic inflammation, and cancer. Therefore, the development of inhibitors of the enzymes that are responsible for the synthesis and degradation of these metabolites may be essential tools for studying normal cell metabolism as well as for establishing new therapeutic strategies for treatment of disease.

AB - The simple sphingolipids ceramide, sphingosine, ceramide 1-phosphate and sphingosine 1-phosphate, and their metabolizing enzymes are implicated in the regulation of vital cellular functions, including angiogenesis, celldifferentiation, migration, and cell growth and death. These sphingolipids are also involved in the establishment and progression of many illnesses including cardiovascular diseases such as atherosclerosis, or neurodegenerative diseases such as Parkinson's or Alzheimer's diseases, chronic inflammation, and cancer. Therefore, the development of inhibitors of the enzymes that are responsible for the synthesis and degradation of these metabolites may be essential tools for studying normal cell metabolism as well as for establishing new therapeutic strategies for treatment of disease.

KW - Apoptosis

KW - Cell migration

KW - Cell proliferation

KW - Ceramide-1-phosphate

KW - Ceramides

KW - Inflammation

KW - Sphingolipids

KW - Sphingosine 1-phosphate

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Inhibition of ceramide metabolism key enzymes and its implication in cell physiology and pathology

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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