Abstract
Treatment of BGM (African Green Monkey kidney) cells with the calcium antagonist Verapamil resulted in a reduced yield of chlamydial infectious particles. The inhibitory effect was concentration-dependent, the maximal effect being achieved at 200 μM-Verapamil, which produced a 99.99% reduction of infectious particle yield. Electron microscopy showed that control Chlamydia trachomatis-infected BGM cells contained typical large inclusions in which most of the particles were elementary bodies, whereas Verapamil-treated infected cells contained small inclusions consisting predominantly of reticulate bodies. The findings indicate a possible therapeutic use of this calcium antagonist as an anti-chlamydial drug.
| Original language | English |
|---|---|
| Pages (from-to) | 1619-1623 |
| Number of pages | 5 |
| Journal | Journal of General Microbiology |
| Volume | 135 |
| Issue number | 6 |
| State | Published - 1 Jan 1989 |
ASJC Scopus subject areas
- Microbiology