Inhibition of growth of Chlamydia trachomatis by human gamma interferon

Y. Shemer; I. Sarov

doi:10.1128/iai.48.2.592-596.1985

Inhibition of growth of Chlamydia trachomatis by human gamma interferon

Y. Shemer
, I. Sarov

The Shraga Segal Department of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Treatment of HEp-2 cell cultures with highly purified human gamma interferon before infection resulted in the reduction of Chlamydia trachomatis (L₂/434/Bu) infectious particle yield. Electron microscope studies showed that interferon did not affect chlamydial conversion to reticulate bodies but influenced the extent of maturation to elementary bodies. High interferon concentrations (>350 IU/ml) inhibited inclusion body formation and resulted in the appearance of aberrant reticulate bodies.

Original language	English
Pages (from-to)	592-596
Number of pages	5
Journal	Infection and Immunity
Volume	48
Issue number	2
DOIs	https://doi.org/10.1128/iai.48.2.592-596.1985
State	Published - 1 Jan 1985

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/iai.48.2.592-596.1985

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title = "Inhibition of growth of Chlamydia trachomatis by human gamma interferon",

abstract = "Treatment of HEp-2 cell cultures with highly purified human gamma interferon before infection resulted in the reduction of Chlamydia trachomatis (L2/434/Bu) infectious particle yield. Electron microscope studies showed that interferon did not affect chlamydial conversion to reticulate bodies but influenced the extent of maturation to elementary bodies. High interferon concentrations (>350 IU/ml) inhibited inclusion body formation and resulted in the appearance of aberrant reticulate bodies.",

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AB - Treatment of HEp-2 cell cultures with highly purified human gamma interferon before infection resulted in the reduction of Chlamydia trachomatis (L2/434/Bu) infectious particle yield. Electron microscope studies showed that interferon did not affect chlamydial conversion to reticulate bodies but influenced the extent of maturation to elementary bodies. High interferon concentrations (>350 IU/ml) inhibited inclusion body formation and resulted in the appearance of aberrant reticulate bodies.

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Inhibition of growth of Chlamydia trachomatis by human gamma interferon

Abstract

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